TSLP molecular target information overview
Overview of TSLP molecular targets
Thymic stromal lymphopoietin (TSLP) is mainly produced by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells. It mainly affects myeloid cells, induces monocytes to release T cell-capturing chemokines and enhances the maturation of myeloid (CD11c+) dendritic cells. Studies have shown that TSLP can also activate the maturation of Langerhans cells, a specific dendritic cell subset located in the epidermis. Activation of myeloid and plasmacytoid (CD123+) dendritic cells by thymic TSLP leads to the production of regulatory T cells. TSLP generates signals through a heterodimeric receptor complex composed of the thymic stromal lymphocyte receptor CRLF2 and the IL-7Rα chain. Binding to STAT5 induces its phosphorylation, which in turn leads to the expression of upstream transcription factors. TSLP expression is associated with many diseases including asthma, inflammatory arthritis, atopic dermatitis, eczema and other allergic conditions.
Human TSLP molecular target information
Molecular name: TSLP, thymic stromal lymphopoietin
Alias:
- None
Gene sequence:NCBI_Gene: 85480
Protein sequence:UniProtKB: Q969D9
Human TSLP target molecular function (prediction)
Enables cytokine activity and interleukin-7 receptor binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Located in extracellular region. Biomarker of common cold and respiratory syncytial virus infectious disease.
Mouse Tslp molecular target information
Molecular name: Tslp, thymic stromal lymphopoietin
Alias:
- None
Gene sequence:NCBI_Gene: 53603
Protein sequence:
Mouse Tslp target molecular function (prediction)
Enables cytokine activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in ductus deferens; epididymis; ileum; Orthologous to human TSLP (thymic stromal lymphopoietin).
Rat Tslp molecular target information
Molecular name: Tslp, thymic stromal lymphopoietin
Synonyms:
- LOC688621
- similar to thymic stromal lymphopoietin
Gene sequence:NCBI_Gene: 688621
Protein sequence:UniProtKB: A0A0G2JUJ3
Rat Tslp target molecular function (prediction)
Predicted to enable cytokine activity and interleukin-7 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Orthologous to human TSLP (thymic stromal lymphopoietin).