ANGPT1 molecular target information overview
Overview of ANGPT1 molecular targets
Angiopoietin is part of the family of vascular growth factors that play a role in embryonic and neovascularization. Angiopoietin cytokines regulate microvascular permeability, vasodilation, and vasoconstriction by signaling to perivascular smooth muscle cells. Angiopoietin-1 (ANG-1) encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa that can form dimers, trimers, and tetramers. It plays an important role in vascular maturation, adhesion, migration, and survival. Studies have shown that the ratio of ANG-2 to ANG-1 in serum is increased, indicating that abnormalities in the angiopoietin and tyrosine kinase pathways are common in blood-related diseases such as diabetes, malaria, sepsis, and pulmonary hypertension.
Human ANGPT1 Molecular Target Information
Molecular name: ANGPT1, angiopoietin 1
Alias:
- AGP1
- AGPT
- ANG-1
- ANG1
- angiopoietin-1
- HAE5
Gene sequence:NCBI_Gene: 284
Protein sequence:UniProtKB: Q15389
Human ANGPT1 target molecular function (prediction)
Enables receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and regulation of vascular permeability. Located in several cellular components, including extracellular space; membrane raft; and microvillus. Implicated in brain ischemia; diabetic retinopathy; and hypertension. Biomarker of carcinoma (multiple); hypertension; and ovarian cancer.
Mouse Angpt1 molecular target information
Molecular name: Angpt1, angiopoietin 1
Alias:
- 1110046O21Rik
- Ang-1
- ang1
- Angiopoietin-1
- RIKEN cDNA 1110046O21 gene
Gene sequence:NCBI_Gene: 11600
Protein sequence:
Mouse Angpt1 target molecular function (prediction)
Enables signaling receptor binding activity. Acts upstream of or within several processes, including blood vessel development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to be located in membrane raft; microvillus; and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cardiovascular system; liver; lung; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
Rat Angpt1 molecular target information
Molecular name: Angpt1, angiopoietin 1
Alias:
- Agpt
- Agpt1
- Ang-1
- angiopoietin
- angiopoietin-1
- LOC360422
Gene sequence:NCBI_Gene: 89807
Protein sequence:
Rat Angpt1 target molecular function (prediction)
Enables identical protein binding activity. Involved in several processes, including animal organ development; response to estrogen; and response to vitamin B3. Located in extracellular space. Biomarker of gastric ulcer; in situ carcinoma; myocardial infarction; nephrosis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. 1).