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TNFRSF8 molecular target information overview


  • Molecular name: TNFRSF8, TNF receptor superfamily member 8
  • Gene family: CD molecules; Tumor necrosis factor receptor superfamily
  • Alias: KI-1
  • Former name: CD30; D1S166E
  • Alias: tumor necrosis factor receptor superfamily, member 8


    • Overview of TNFRSF8 molecular targets


    Leukocyte antigen cluster of differentiation 30 (CD30), also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8), is a membrane protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated but not resting T and B cells. CD30 may play a role in the regulation of cell growth and transformation of activated lymphoblasts and may also play an important role in human immunodeficiency virus replication. TRAF2 and TRAF5 can interact with this receptor and mediate signal transduction leading to NF-κB activation. As a positive regulator of apoptosis, CD30 protein can induce cell death or proliferation depending on the cell type and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body from autoimmunity. CD30 protein expression is upregulated in various hematological malignancies and CD30 has also been associated with leukocytes in patients with chronic inflammatory diseases such as lupus erythematosus, asthma, and rheumatoid arthritis.


    Human TNFRSF8 molecular target information


    Molecular name: TNFRSF8, TNF receptor superfamily member 8


    Alias:

    • CD30
    • CD30 antigen
    • CD30L receptor
    • cytokine receptor CD30
    • D1S166E
    • Ki-1
    • Ki-1 antigen
    • lymphocyte activation antigen CD30
    • tumor necrosis factor receptor superfamily member 8
    • tumor necrosis factor receptor superfamily, member 8

    Gene sequence:NCBI_Gene: 943

    Protein sequence:UniProtKB: P28908


    Human TNFRSF8 target molecular function (prediction)


    Predicted to enable transmembrane signaling receptor activity. Involved in cellular response to mechanical stimulus; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Located in plasma membrane.


    Mouse Tnfrsf8 molecular target information


    Molecular name:Tnfrsf8, tumor necrosis factor receptor superfamily, member 8


    Other Names:

    • CD30
    • Cd30
    • CD30 antigen


    Gene sequence:NCBI_Gene: 21941

    Protein sequence:


    Mouse Tnfrsf8 target molecular function (prediction)


    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Predicted to be located in plasma membrane. Is expressed in several structures, including adrenal gland; brain; female reproductive system; intestine; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8).


    Rat Tnfrsf8 molecular target information


    Molecular name: Tnfrsf8, TNF receptor superfamily member 8

    Alias:

    • Cd30
    • CD30L receptor
    • lymphocyte activation antigen CD30
    • tumor necrosis factor receptor superfamily member 8
    • tumor necrosis factor receptor superfamily, member 8
    • Tumor necrosis factor superfamily member 8
    • tumor necrosis factor superfamily member CD30
    • tumor necrosis factor superfamily, member CD30

    Gene sequence:NCBI_Gene: 25069

    Protein sequence:


    Rat Tnfrsf8 target molecular function (prediction)


    Predicted to enable transmembrane signaling receptor activity. Involved in positive regulation of NF-kappaB transcription factor activity. Predicted to be located in plasma membrane. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8).