IFNA1 molecular target information overview
Overview of IFNA1 molecular targets
Interferons (IFNs) are a group of signaling proteins synthesized and released by host cells in response to pathogens such as viruses, bacteria, parasites, or tumor cells. Under normal circumstances, virus-infected cells release interferons to enable surrounding cells to improve their antiviral defenses. Based on the type of receptor, human interferons can be divided into three major types: type I interferons, including IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω, type II interferons (called IFN-γ in humans), and type III interferons. IFN-α protein is produced by white blood cells and is mainly involved in innate immunity in response to viral infections. Studies have shown that enhancing the expression of IFN-α in tumor-infiltrating macrophages can lead to more effective dendritic cell activation and immune effector cytotoxicity. IFN-α, as a pyrogenic factor, can cause fever by changing the activity of heat-sensitive neurons in the hypothalamus. Using a similar mechanism, IFN-α can be used to relieve pain and interact with the μ-opioid receptor to act as an analgesic.
Human IFNA1 molecular target information
Molecular name: IFNA1, interferon alpha 1
Alias:
- IFL
- IFN
- IFN-ALPHA
- IFN-alpha 1b
- IFN-alpha-1/13
- IFN-alphaD
- IFNA@
- IFNA13
- interferon alpha 1b
- interferon alpha-1/13
- interferon alpha-D
- interferon-alpha1
- interferon, alpha 1
- leIF D
- MGC138207
- MGC138505
- MGC138507
Gene sequence:NCBI_Gene: 3439
Protein sequence: UniProtKB: P01562
Human IFNA1 target molecular function (prediction)
Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein.
Mouse Ifna1 molecular target information
Molecular name: Ifna1, interferon alpha 1
Alias:
- Ifa1
Gene sequence:NCBI_Gene: 15962
Protein sequence:
Mouse Ifna1 target molecular function (prediction)
Enables cytokine activity. Involved in regulation of defense response to virus by host and type I interferon signaling pathway. Acts upstream of or within defense response to other organism and lymphocyte activation involved in immune response. Located in extracellular space. Is expressed in embryo. IFNA10 (interferon alpha 10); IFNA14 (interferon alpha 14); and IFNA16 (interferon alpha 16).