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CCL27 molecular target information overview


  • Molecular name: CCL27, CC motif chemokine ligand 27
  • Gene family: Chemokine ligands
  • Aliases: ALP; ILC; CTACK; skinkine; ESkine; PESKY; CTAK
  • Former name: SCYA27
  • Alias: CC chemokine ILC; IL-11 Ralpha-locus chemokine; cutaneous T-cell attracting chemokine; small inducible cytokine subfamily A (Cys-Cys), member 27; chemokine (CC motif) ligand 27


    • CCL27 molecular target review


    Chemokine ligand 27 (CCL27), also known as skin T cell capture chemokine (CTACK), is a small molecular weight cytokine in the CC chemokine family, and its gene is located on human chromosome 9. CCL27 is expressed in many tissues, including gonads, thymus, placenta, and skin. In vitro studies have shown that IL-1β or TNF-α can stimulate CCL27 overexpression, while glucocorticoid can inhibit its expression. CCL27 exerts its chemotactic effect by binding to the chemokine receptor CCR10, which is associated with the homing of memory T lymphocytes to the skin and plays a role in T cell-mediated skin inflammation. In healthy mice, lymphocytes are recruited at the site of CCL27 injection, while in a mouse contact hypersensitivity model, injection of CCL27 neutralizing antibodies disrupts lymphocyte recruitment.


    Human CCL27 Molecular Target Information


    Molecular name: CCL27, CC motif chemokine ligand 27


    Alias:

    • ALP
    • CC motif chemokine 27
    • CC chemokine ILC
    • chemokine (CC motif) ligand 27
    • CTACK
    • CTAK
    • cutaneous T-cell attracting chemokine
    • cutaneous T-cell-attracting chemokine
    • ESKINE
    • IL-11 R-alpha-locus chemokine
    • IL-11 Ralpha-locus chemokine
    • ILC
    • PESKY
    • SCYA27
    • skinkine
    • small inducible cytokine subfamily A (Cys-Cys), member 27
    • small-inducible cytokine A27

    Gene sequence:NCBI_Gene: 10850

    Protein sequence:UniProtKB: Q9Y4X3


    Human CCL27 target molecular function (prediction)


    Enables CCR3 chemokine receptor binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in nucleus. Predicted to be active in extracellular region. Biomarker of COVID-19; asthma; and atopic dermatitis.


    Mouse Ccl27a molecular target information


    Molecular name: Ccl27a, chemokine (CC motif) ligand 27A


    Alias:

    • ALP
    • AW558992
    • Ccl27
    • chemokine (CC motif) ligand 27
    • chemokine (CC motif) ligand 27a
    • CTACK
    • CTAK
    • ESkine
    • expressed sequence AW558992
    • ILC
    • mILC
    • PESKY
    • Scya27
    • Scya27a
    • skinskine
    • small inducible cytokine A27
    • small inducible cytokine A27a


    Gene sequence:NCBI_Gene: 20301

    Protein sequence:


    Mouse Ccl27a target molecular function (prediction)


    Acts upstream of or within positive regulation of T cell chemotaxis and positive regulation of actin cytoskeleton reorganization. Located in extracellular region and nucleus. Is expressed in several structures, including genitourinary system; hip; liver; sensory organ; and skeleton. Orthologous to human CCL27 (CC motif chemokine ligand 27).


    Rat Ccl27 molecular target information


    Molecular name: Ccl27, CC motif chemokine ligand 27

    Alias:

    • CC motif chemokine 27
    • chemokine (CC motif) ligand 27
    • LOC362505

    Gene sequence:NCBI_Gene: 362505

    Protein sequence:UniProtKB: D4AAL6


    Rat Ccl27 target molecule function (prediction)


    Predicted to enable CCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; positive of T cell chemotaxis regulation; and positive regulation of actin cytoskeleton reorganization. Predicted to act upstream of or within positive regulation of mononuclear cell migration. Predicted to be located in nucleus. Predicted to be active in extracellular region. Orthologous to human CCL27 (CC motif chemokine ligand 27).