CD28 molecular target information overview
CD28 molecular target review
CD28 is a 45 kDa homodimer expressed in most thymocytes and expressed at low levels in most peripheral CD4+ and CD8+ T cells and NK cells. It is also expressed in activated splenocytes, mast cells and thymocytes. CD28 is a co-stimulatory molecule of T cells and a ligand for CD80 (B7-1) and CD86 (B7-2). CD28 signaling can stimulate the expression of IL-2 and its receptors, as well as the cytotoxicity of CD3-activated T cells. The antibody can stimulate the proliferation of T cells and NK cells and promote their secretion of cytokines.
Human CD28 Molecular Target Information
Molecular name: CD28, CD28 molecule
Alias:
- CD28 antigen
- MGC138290
- T-cell-specific surface glycoprotein CD28
- Tp44
Gene sequence:NCBI_Gene: 940
Protein sequence:UniProtKB: P10747
Human CD28 target molecule function (prediction)
Enables protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of mitotic nuclear division; and regulatory T cell differentiation. Located in external side of plasma membrane. Part of protein complex involved in cell adhesion. Implicated in multiple sclerosis and type 1 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); chronic fatigue syndrome; diabetic angiopathy; lung disease (multiple); and respiratory syncytial viral infectious disease.
Mouse Cd28 molecular target information
Molecular name: Cd28, CD28 antigen
Alias:
- None
Gene sequence:NCBI_Gene: 12487
Protein sequence:
Mouse Mouse Cd28 Target Molecular Function (Prediction)
Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).
Rat Cd28 molecular target information
Molecular name: Cd28, Cd28 molecule
Alias:
- CD28 antigen
- CD28RNA
- T-cell-specific surface glycoprotein CD28
Gene sequence:NCBI_Gene: 25660
Protein sequence:
Rat Cd28 target molecular function (prediction)
Enables identical protein binding activity. Involved in T cell activation and T cell costimulation. Located in membrane raft. Used to study lymphopenia. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).