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GC molecular target information overview


  • Molecular name: GC, GC vitamin D binding protein
  • Alias: DBP; VDBP; hDBP
  • Alias: group-specific component (vitamin D binding protein); GC, vitamin D binding protein


    • Overview of GC molecular targets


    Vitamin D binding protein (VitaminDBP), also known as gc (group-specific component) globulin, belongs to the albumin gene family along with human serum albumin and alpha-fetoprotein. It has multiple functions and is present in plasma, ascites, cerebrospinal fluid, and on the surface of many types of cells. It binds to vitamin D and its metabolites and transports them to target tissues. As a macrophage activating factor derived from Gc protein, VitaminDBP can be used in cancer treatment to activate macrophages to resist tumor cells.


    Human GC Molecular Target Information


    Molecular name: GC, GC vitamin D binding protein


    Alias:

    • DBP
    • DBP-maf
    • DBP/GC
    • epididymis secretory protein Li 51
    • gc protein-derived macrophage activating factor
    • gc-globulin
    • Gc-MAF
    • GcMAF
    • GRD3
    • group-specific component (vitamin D binding protein)
    • HEL-S-51
    • VDB
    • VDBG
    • VDBP
    • vitamin D-binding alpha-globulin
    • vitamin D-binding protein
    • vitamin D-binding protein-macrophage activating factor

    Gene sequence:NCBI_Gene: 2638

    Protein sequence:UniProtKB: P02774


    Human GC target molecular function (prediction)


    Enables actin binding activity and calcidiol binding activity. Predicted to be involved in vitamin transport. Predicted to act upstream of or within vitamin D metabolic process. Located in blood microparticle and extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Biomarker of several diseases, including autoimmune disease (multiple); dengue disease; diabetic retinopathy; hepatic encephalopathy; and sciatic neuropathy.


    Mouse Gc molecular target information


    Molecular name: Gc, vitamin D binding protein


    Alias:

    • DBP


    Gene sequence:NCBI_Gene: 14473

    Protein sequence:


    Mouse Gc target molecular function (prediction)


    Predicted to enable actin binding activity and calcidiol binding activity. Acts upstream of or within vitamin D metabolic process. Predicted to be located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).


    Rat Gc molecular target information


    Molecular name: Gc, GC, vitamin D binding protein

    Alias:

    • DBP
    • DBP02
    • gc-globulin
    • group specific component
    • group-specific component
    • Group-specific component (vitamin D-binding protein)
    • RATDBP02
    • VDB
    • Vdbp
    • vitamin D-binding protein

    Gene sequence:NCBI_Gene: 24384

    Protein sequence:


    Rat Gc target molecular function (prediction)


    Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).