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CCL22 molecular target information overview


  • Molecular name: CCL22, CC motif chemokine ligand 22
  • Gene family: Chemokine ligands
  • Aliases: MDC; STCP-1; ABCD-1; DC/B-CK; A-152E5.1; MGC34554
  • Former name: SCYA22
  • Alias: small inducible cytokine subfamily A (Cys-Cys), member 22; chemokine (CC motif) ligand 22


    • CCL22 molecular target review


    Chemokine ligand 22 (CCL22), also known as macrophage-derived chemokine (MDC), is a member of the CC chemokine family. B cells, microglia, dendritic cells, macrophages, monocytes, interferon-γ activated keratinocytes, colon epithelial cells, CD4+ T cells, thymic medullary epithelial cells (bodies), and activated NK cells can express CCL22. CCL22 plays an important role in lymphocyte migration and is an effective chemoattractant for cell types such as dendritic cells, thymocytes, and activated NK cells. CCL22 produced by antigen-presenting dendritic cells chemotactic activated (or memory) T cells carrying CCR4, thereby enhancing the body's immune response and increasing effector function. CCL22 also has other functions, including activation of platelet function and inhibition of synaptic transmission between hippocampal neurons.


    Human CCL22 Molecular Target Information


    Molecular name: CCL22, CC motif chemokine ligand 22


    Alias:

    • A-152E5.1
    • ABCD-1
    • CC motif chemokine 22
    • CC chemokine STCP-1
    • chemokine (CC motif) ligand 22
    • DC/B-CK
    • macrophage-derived chemokine
    • MDC
    • MDC(1-69)
    • MGC34554
    • SCYA22
    • small inducible cytokine A22
    • small inducible cytokine subfamily A (Cys-Cys), member 22
    • small-inducible cytokine A22
    • STCP-1
    • stimulated T cell chemotactic protein 1
    • stimulated T-cell chemotactic protein 1

    Gene sequence:NCBI_Gene: 6367

    Protein sequence:UniProtKB: O00626


    Human CCL22 target molecular function (prediction)


    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including arthritis (multiple); cervical squamous cell carcinoma; lung disease (multiple); pleural tuberculosis; and rhinitis.


    Mouse Ccl22 molecular target information


    Molecular name: Ccl22, chemokine (CC motif) ligand 22


    Alternate names:

    • ABCD-1
    • MDC
    • Scya22
    • small inducible cytokine subfamily A22


    Gene sequence:NCBI_Gene: 20299

    Protein sequence:


    Mouse Ccl22 Target Molecular Function (Prediction)


    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within chemotaxis. Located in extracellular space. Is expressed in inguinal lymph node; thymus; and thymus primordium. Orthologous to human CCL22 (CC motif chemokine ligand 22).


    Rat Ccl22 molecular target information


    Molecular name: Ccl22, CC motif chemokine ligand 22

    Alias:

    • CC motif chemokine 22
    • chemokine (CC motif) ligand 22
    • Mdc
    • MGC108943
    • Scya22
    • small inducible cytokine A22
    • small inducible cytokine subfamily A (Cys-Cys) member 22
    • small inducible cytokine subfamily A (Cys-Cys), member 22

    Gene sequence:NCBI_Gene: 117551

    Protein sequence:UniProtKB: Q5I0L5


    Rat Ccl22 target molecule function (prediction)


    Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in extracellular space. Used to study anti-basement membrane glomerulonephritis. Biomarker of asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL22 (CC motif chemokine ligand 22).