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Overview of NPPC molecular target information


  • Molecular name: NPPC, natriuretic peptide C
  • Gene family: Neuropeptides
  • Alias: CNP
  • Alias: natriuretic peptide precursor C


    • Overview of NPPC molecular targets


    C-peptide, also known as connecting peptide, is secreted by pancreatic β cells and has a common precursor, proinsulin, with insulin. It is a 31-amino acid polypeptide that connects the A chain and B chain of insulin in the proinsulin molecule. C-peptide has been shown to bind to G protein-coupled receptors on the surface of many types of cells (such as neurons, endothelial cells, fibroblasts, and renal tubules) at nanomolar concentrations. C-peptide exerts vascular anti-inflammatory effects by downregulating adhesion molecules on the surface of endothelial cells, reducing the production of inflammatory cytokines, and protecting vascular smooth muscle cells from harmful insulin effects. In animals with C-peptide-deficient (type 1 model) nephropathy, administration of C-peptide can improve renal function and structure, reduce urinary albumin excretion, and prevent or reduce diabetes-induced glomerular changes due to mesangial matrix expansion.


    Human NPPC Molecular Target Information


    Molecular name: NPPC, natriuretic peptide C


    Alias:

    • C-type natriuretic peptide
    • CNP
    • CNP2
    • natriuretic peptide precursor C
    • natriuretic peptide precursor type C

    Gene sequence:NCBI_Gene: 4880

    Protein sequence:UniProtKB: P23582


    Human NPPC target molecular function (prediction)


    Enables hormone receptor binding activity. Involved in protein folding and receptor guanylyl cyclase signaling pathway. Acts upstream of or within negative regulation of meiotic cell cycle and negative regulation of oocyte maturation. Part of protein-containing complex. Implicated in hypertension. Biomarker of arteriosclerosis; end stage renal disease; hypertension; and toxic shock syndrome.


    Mouse Nppc molecular target information


    Molecular name: Nppc, natriuretic peptide type C


    Alias:

    • CNP
    • lbab
    • long bone abnormality
    • natriuretic peptide precursor C


    Gene sequence:NCBI_Gene: 18159

    Protein sequence:


    Mouse Nppc target molecular function (prediction)


    Enables signaling receptor binding activity. Involved in growth plate cartilage chondrocyte differentiation and growth plate cartilage chondrocyte proliferation. Acts upstream of or within several processes, including negative regulation of meiotic cell cycle; negative regulation of oocyte maturation; and regulation of growth. Predicted to be located in extracellular space and secretory granule. Predicted to be part of protein-containing complex. Is expressed in central nervous system and vertebral cartilage condensation. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).


    Rat Nppc molecular target information


    Molecular name: Nppc, natriuretic peptide C

    Alias:

    • C-type natriuretic peptide
    • natriuretic peptide precursor C
    • natriuretic peptide precursor type C

    Gene sequence:NCBI_Gene: 114593

    Protein sequence:UniProtKB: P55207


    Rat Nppc target molecular function (prediction)


    Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).