Blog

FGF21 molecular target information overview


  • Molecular name: FGF21, fibroblast growth factor 21
  • Gene family: Fibroblast growth factor family


    • Review of FGF21 molecular targets


    Fibroblast growth factor 21 (FGF-21) is expressed in many tissues, including the liver, brown adipose tissue, white adipose tissue, and pancreas. In mice, circulating FGF-21 originates from the liver. FGF-21 promotes glucose uptake by adipocytes but has no effect on other cell types. Serum FGF-21 is significantly elevated in patients with type 2 diabetes mellitus (T2DM), indicating its role in the pathogenesis of T2DM. Elevated FGF-21 is also associated with liver fat content in non-alcoholic fatty liver disease and is positively correlated with human BMI, suggesting that obesity is a result of tolerance to FGF-21.


    Human FGF21 Molecular Target Information


    Molecular name:FGF21, fibroblast growth factor 21


    Other Names:

    • FGF-21

    Gene sequence:NCBI_Gene: 26291

    Protein sequence:UniProtKB: Q9NSA1


    Human FGF21 target molecular function (prediction)


    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glucose import. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Biomarker of atherosclerosis; chronic kidney disease; and fatty liver disease.


    Mouse Fgf21 molecular target information


    Molecular name:Fgf21, fibroblast growth factor 21


    Alias:

    • None


    Gene sequence:NCBI_Gene: 56636

    Protein sequence:


    Mouse Fgf21 target molecular function (prediction)


    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; cerebellum; integumental system; limb; and skeleton. Orthologous to human FGF21 (fibroblast growth factor twenty one).


    Rat Fgf21 molecular target information


    Molecular name:Fgf21, fibroblast growth factor 21

    Alias:

    • Fgf8c
    • fibroblast growth factor 8c

    Gene sequence:NCBI_Gene: 170580

    Protein sequence:UniProtKB: Q8VI80


    Rat Fgf21 target molecular function (prediction)


    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including cellular response to glucagon stimulus; endothelial cell apoptotic process; and negative regulation of cell death. Located in extracellular space. Orthologous to human FGF21 (fibroblast growth factor 21).