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SERPINC1 Molecular Target Information Overview


  • Molecular name: SERPINC1, serpin family C member 1
  • Gene family: Serpin peptidase inhibitors
  • Alias: ATIII; MGC22579
  • Previous name: AT3
  • Alias: antithrombin III; signal peptide antithrombin part 1; coding sequence signal peptide antithrombin part 1; antithrombin (aa 375-432); serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1


    • Overview of SERPINC1 molecular targets


    Antithrombin-III is a member of the Serpin superfamily of serine protease inhibitors and is encoded by the SerpinC1 gene. Studies have found that Antithrombin-III is a marker for disseminated intravascular coagulation (DIC). This protein can inhibit thrombin and other activated serine protease coagulation systems and regulate the coagulation cascade. Antithrombin-III is the most important coagulation factor inhibitor. Even if there is a slight change in Antithrombin-III, it can significantly increase the risk of thromboembolism. Antithrombin-III can inhibit inflammation through dependent coagulation effects or independent coagulation effects. In addition, in addition to Antithrombin-III deficiency, Antithrombin-III and its encoding gene SerpinC1 may also be associated with many diseases (such as hypertension and kidney disease).


    Human SERPINC1 Molecular Target Information


    Molecular name: SERPINC1, serpin family C member 1


    Alias:

    • antithrombin III
    • antithrombin III isoform
    • antithrombin-III
    • AT3
    • AT3D
    • ATIII
    • ATIII-R2
    • ATIII-T1
    • ATIII-T2
    • MGC22579
    • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
    • serine-cysteine proteinase inhibitor clade C member 1
    • serpin C1
    • serpin peptidase inhibitor clade C member 1
    • serpin peptidase inhibitor, clade C (antithrombin), member 1
    • THPH7

    Gene sequence:NCBI_Gene: 462

    Protein sequence:UniProtKB: P01008


    Human SERPINC1 target molecular function (prediction)


    Enables identical protein binding activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Biomarker of acute kidney failure; nephrotic syndrome; osteonecrosis; and type 2 diabetes mellitus.


    Mouse Serpinc1 molecular target information


    Molecular name:Serpinc1, serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1


    Alias:

    • AI114908
    • anti-thrombin 3
    • antithrombin
    • At-3
    • At3
    • ATIII
    • expressed sequence AI114908


    Gene sequence:NCBI_Gene: 11905

    Protein sequence:


    Mouse Serpinc1 target molecular function (prediction)


    Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to nutrient. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in embryo; deficiency. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).


    Rat Serpinc1 molecular target information


    Molecular name: Serpinc1, serpin family C member 1

    Alias:

    • antithrombin III
    • antithrombin-III
    • LOC304917
    • serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
    • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
    • serpin peptidase inhibitor, clade C (antithrombin), member 1

    Gene sequence:NCBI_Gene: 304917

    Protein sequence:


    Rat Serpinc1 target molecular function (prediction)


    Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).