CRP molecular target information overview
Overview of CRP molecular targets
C-reactive protein (CRP) is a cyclic, pentameric protein found in plasma. CRP is synthesized by the liver in response to factors released by macrophages and adipocytes. CRP is a liver-derived acute protein that increases after the secretion of interleukin-6 by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine on the surface of dead or dying cells (and certain types of bacteria) to activate the complement system through the C1Q complex. It is not related to C-peptide (insulin) or protein C (blood coagulation). CRP is often used as a marker of inflammation, and CRP levels will increase when the body is infected with inflammation. Recent studies have shown that patients with higher baseline levels of CRP are often accompanied by a higher incidence of diabetes, hypertension and cardiovascular disease.
Human CRP molecular target information
Molecular name: CRP, C-reactive protein
Alias:
- C-reactive protein, pentraxin-related
- c-reactive protein, petaxin related
- MGC149895
- MGC88244
- pentraxin 1
- PTX1
Gene sequence:NCBI_Gene: 1401
Protein sequence:UniProtKB: P02741
Human CRP target molecular function (prediction)
Enables several functions, including complement component C1q complex binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including negative regulation of macrophage derived foam cell differentiation; positive regulation of superoxide anion generation; and regulation of gene expression. Acts upstream of or within vasoconstriction. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple).
Mouse Crp molecular target information
Molecular name: Crp, C-reactive protein, pentraxin-related
Alias:
- AI255847
- expressed sequence AI255847
Gene sequence:NCBI_Gene: 12944
Protein sequence:
Mouse Crp target molecular function (prediction)
Predicted to enable several functions, including cholesterol binding activity; complement component C1q complex binding activity; and low-density lipoprotein particle binding activity. Predicted to be involved in several processes, including complement activation, classical pathway; regulation of gene expression; and regulation of superoxide anion generation. Predicted to act upstream of or within vasoconstriction. liver. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein).
Rat Crp molecular target information
Molecular name: Crp, C-reactive protein
Alias:
- Aa1249
- Ab1-341
- Ab2-196
- Ac1-114
- Ac1262
- Ac2-069
- Ba2-693
- C-reactive protein member of the pentraxin family
- C-reactive protein, member of the pentraxin family
- C-reactive protein, pentraxin-related
- C-reactive protein, petaxin related
Gene sequence:NCBI_Gene: 25419
Protein sequence:
- UniprotKB: A0A0G2K8V5
- UniprotKB: H6X2V2
- UniprotKB: H6X2V3
- UniprotKB: H6X2V4
- UniprotKB: H6X2V7
- UniprotKB: H6X2V8
- UniprotKB: H6X2V9
- UniprotKB: H6X2W0
- UniprotKB: H6X2W1
- UniprotKB: H6X2W2
- UniprotKB: H6X2W3
- UniprotKB: H6X2W4
- UniprotKB: H6X2W5
- UniprotKB: H6X2W6
- UniprotKB: H6X2W7
- UniprotKB: H6X2X0
- UniprotKB: P48199
- UniprotKB: Q63133
- UniprotKB: Q63134
Rat Crp target molecular function (prediction)
Enables cholesterol binding activity; identical protein binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including cellular response to nitric oxide; complement activation, classical pathway; and negative regulation of superoxide anion generation. Located in extracellular space; filopodium; epilepticus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein).