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PRL molecular target information overview


  • Molecular name: PRL, prolactin
  • Gene family: Growth hormone family; Neuropeptides


    • Overview of PRL molecular targets


    Prolactin (PRL) is a neuroendocrine pituitary hormone encoded by the PRL gene and synthesized by the pituitary, placenta, brain, uterus, dermal fibroblasts, decidua, B cells, T cells, natural killer cells, and breast cancer cells. Prolactin expression is low in early human pregnancy and is replaced by placental lactogen, but expression increases in late pregnancy. Prolactin plays an important role in metabolism, immune system regulation, and pancreatic development. Prolactin also acts in a cytokine-like manner and is an important regulator of the immune system. As a growth, differentiation, and anti-apoptotic factor, it has important cell cycle-related functions. As a growth factor that binds to cytokine-like receptors, it can affect hematopoiesis, angiogenesis, and participate in the regulation of blood coagulation through multiple pathways.


    Human PRL molecular target information


    Molecular name:PRL, prolactin


    Alias:

    • decidual prolactin
    • GHA1
    • growth hormone A1

    Gene sequence:NCBI_Gene: 5617

    Protein sequence: UniProtKB: P01236


    Human PRL target molecular function (prediction)


    Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive of receptor signaling pathway via JAK-STAT. Predicted to be located in secretory granule. syndrome.


    Mouse Prl molecular target information


    Molecular name: Prl, prolactin


    Alias:

    • AV290867
    • expressed sequence AV290867
    • Prl1a1


    Gene sequence:NCBI_Gene: 19109

    Protein sequence:


    Mouse Prl target molecular function (prediction)


    Predicted to enable hormone activity and prolactin receptor binding activity. Acts upstream of or within several processes, including mammary gland development; maternal behavior; and positive regulation of receptor signaling pathway via JAK-STAT. Located in secretory granule. Is expressed in hippocampus; pituitary gland; placenta; and trophoblast giant cell. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).


    Rat Prl molecular target information


    Molecular name: Prl, prolactin

    Alias:

    • Gha1
    • growth hormone a1
    • Prl1a1
    • PRLB
    • PRLSD1
    • Prol
    • prolactin family 1, subfamily a, member 1
    • RATPRLSD1
    • RNPROL

    Gene sequence:NCBI_Gene: 24683

    Protein sequence:


    Rat Prl target molecular function (prediction)


    Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including parturition; response to estradiol; and response to lipopolysaccharide. Located in extracellular region and secretory granule. Used to study portal hypertension and prolactinoma. Biomarker of hyperprolactinemia; prolactinoma; and renovascular hypertension. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).