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Overview of LTA molecular target information


  • Molecular name: LTA, lymphotoxin alpha
  • Gene family: Tumor necrosis factor superfamily
  • Alias: TNFSF1; LT
  • Former name: TNFB
  • Alias: TNF superfamily member 1; lymphotoxin alpha (TNF superfamily, member 1)


    • Overview of LTA molecular targets


    Tumor necrosis factor beta (TNF-β), also known as lymphotoxin alpha, is a cytokine secreted by lymphocytes. TNF-β mediates many inflammatory, immunostimulatory, and antiviral responses. During development, TNF-β is also involved in the formation of secondary lymphoid organs and plays a role in apoptosis. In TNF-β knockout mice, all Peyer's patches and lymph nodes fail to develop, demonstrating the importance of TNF-β in immune development.


    Human LTA Molecular Target Information


    Molecular name: LTA, lymphotoxin alpha


    Alias:

    • CDF
    • cholinergic differentiation factor
    • D factor
    • DIA
    • differentiation inhibitory activity
    • differentiation stimulating factor
    • differentiation-inducing factor
    • differentiation-stimulating factor
    • hepatocyte-stimulating factor III
    • HILDA
    • human interleukin in DA cells
    • leukemia inhibitory factor
    • LIF, interleukin 6 family cytokine
    • melanoma-derived LPL inhibitor
    • MLPLI

    Gene sequence:NCBI_Gene: 4049

    Protein sequence:UniProtKB: P01374


    Human LTA target molecular function (prediction)


    Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.


    Mouse Lta molecular target information


    Molecular name: Lta, lymphotoxin A


    Alias:

    • heart, lung and blood 382
    • hlb382
    • LT
    • LT-[a]
    • LT-alpha
    • LT[a]
    • LTalpha
    • Ltx
    • lymphotoxin
    • lymphotoxin alpha
    • TNF beta
    • TNF-beta
    • Tnfb
    • Tnfsf1b
    • tumor necrosis factor beta


    Gene sequence:NCBI_Gene: 16992

    Protein sequence:


    Mouse Lta target molecular function (prediction)


    Predicted to enable tumor necrosis factor receptor binding activity. Acts upstream of or within several processes, including lymph node development; positive regulation of immune response; and positive regulation of interferon-gamma production. Predicted to be located in extracellular space. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha).


    Rat Lta molecular target information


    Molecular name: Lta, lymphotoxin alpha

    Alias:

    • LOC103690381
    • LT-alpha
    • lymphotoxin A
    • Lymphotoxin alpha (formerly tumor necrosis factor beta)
    • Lymphotoxin alpha (formerly tumor necrosis factor, beta)
    • lymphotoxin alpha (TNF superfamily, member 1)
    • lymphotoxin-alpha
    • lymphotoxin-alpha-like
    • TNF-beta
    • Tnfb
    • tumor necrosis factor beta
    • tumor necrosis factor ligand superfamily member 1

    Gene sequence:NCBI_Gene: 25008

    Protein sequence:UniProtKB: Q06332


    Rat Lta target molecular function (prediction)


    Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha).