CD40LG molecular target information overview
Overview of CD40LG molecular targets
CD40 ligand (CD40L/CD154) is a member of the TNF superfamily of molecules. It is a 39 kDa glycoprotein that is primarily expressed on activated T cells. Soluble CD40L (sCD40L) with a molecular weight of 15-18 kDa is produced by proteolysis. CD40L binds to CD40 on the surface of antigen presenting cells (APCs) and can have a variety of effects depending on the target cell type. CD40L is particularly important as a co-stimulatory molecule for the T cell subset follicular helper T cells (Tfh cells). In Tfh cells, CD40L binds to CD40 on the surface of B cells, promoting B cell maturation and function, thereby promoting cell-to-cell communication. Loss of the CD40L gene results in the inability to switch immunoglobulin classes and is associated with hyper-IgM syndrome. Loss of CD40L also blocks germinal center formation, thereby preventing antibody affinity maturation, an important process in the adaptive immune system.
Human CD40LG Molecular Target Information
Molecular name: CD40LG, CD40 ligand
Alias:
- CD154
- CD40 antigen ligand
- CD40-L
- CD40L
- gp39
- hCD40L
- HIGM1
- IGM
- IMD3
- TB cell-activating molecule
- T-BAM
- T-cell antigen Gp39
- TNF-related activation protein
- TNFSF5
- TRAP
- tumor necrosis factor (ligand) superfamily member 5
Gene sequence:NCBI_Gene: 959
Protein sequence:UniProtKB: P29965
Human CD40LG target molecule function (prediction)
Enables CD40 receptor binding activity and integrin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of apoptotic process. Located in cell surface. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Biomarker of several diseases, including allergic disease rhinitis; autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); and hematologic cancer (multiple).
Mouse Cd40lg molecular target information
Molecular name: Cd40lg, CD40 ligand
Alias:
- CD154
- CD40 antigen ligand
- Cd40l
- Cd40L
- gp39
- HIGM1
- IMD3
- Ly-62
- Ly62
- lymphocyte antigen 62
- T-BAM
- Tnfsf5
- tumor necrosis factor (ligand) superfamily, member 5
Gene sequence:NCBI_Gene: 21947
Protein sequence:
Mouse Mouse Cd40lg target molecular function (prediction)
Predicted to enable CD40 receptor binding activity and integrin binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
Rat Cd40lg molecular target information
Molecular name: Cd40lg, CD40 ligand
Alias:
- CD40 ligand CD154
- CD40-L
- Cd40l
- LOC84349
- Tnfsf5
- tumor necrosis factor (ligand) superfamily, member 5
- tumor necrosis factor ligand superfamily member 5
Gene sequence:NCBI_Gene: 84349
Protein sequence:
Rat Cd40lg target molecular function (prediction)
Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of MHC class II biosynthetic process; and positive regulation of cytokine production. Located in several cellular components, including cell body; cell surface; and extracellular space. Used to study Ehrlich tumor carcinoma; artery disease (multiple); autoimmune disease (multiple); thrombosis; and vitamin B12 deficiency. Biomarker of atherosclerosis; coronary artery disease; perinatal necrotizing enterocolitis; periodontal disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Orthologous to human CD40LG (CD40 ligand).