IL21 molecular target information overview
Overview of IL21 molecular targets
Interleukin 21 (IL-21) has a strong regulatory effect on immune cells, including natural killer (NK) cells and cytotoxic T cells that can destroy virus-infected or tumor cells. This cytokine can induce target cell division/proliferation. IL-21 is expressed in human activated CD4+ T cells, but not in most other tissues. In addition, IL-21 is upregulated in helper T cell subsets Th2 and Th17 cells and follicular T cells. IL-21 is also expressed in NKT cells that regulate the function of these cells. IL-21 has a pathological role in immune-inflammatory diseases. Studies have shown the existence of a positive autocrine loop that can amplify and stabilize IL-21-driven, T cell-mediated responses. In addition, it has anti-tumor activity and has an effect on autoimmune processes. In the clinic, IL-21 can also be used as a potential anti-tumor drug.
Human IL21 Molecular Target Information
Molecular name: IL21, interleukin 21
Alias:
- CVID11
- IL-21
- interleukin-21
- interleukin-21 isoform
- Za11
Gene sequence:NCBI_Gene: 59067
Protein sequence:UniProtKB: Q9HBE4
Human IL21 target molecular function (prediction)
Enables interleukin-2 receptor binding activity. Involved in several processes, including positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; and tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of B cell proliferation; positive regulation of T cell proliferation; variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Biomarker of several diseases, including anogenital venereal wart; autoimmune disease (multiple); dengue hemorrhagic fever; human immunodeficiency virus infectious disease; and tropical spastic paraparesis.
Mouse Il21 molecular target information
Molecular name: Il21, interleukin 21
Alias:
- None
Gene sequence:NCBI_Gene: 60505
Protein sequence:
Mouse Il21 target molecular function (prediction)
Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. regulation Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).
Rat Il21 molecular target information
Molecular name: Il21, interleukin 21
Alias:
- IL-21
- interleukin-21
- LOC365769
Gene sequence:NCBI_Gene: 365769
Protein sequence:UniProtKB: A3QPB9
Rat Il21 target molecular function (prediction)
Predicted to enable interleukin-2 receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune effector process; and tyrosine phosphorylation of STAT protein. disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).