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PDCD1 molecular target information overview


  • Molecular name: PDCD1, programmed cell death 1
  • Gene family: CD molecules; V-set domain containing
  • Other names: CD279; PD1; hSLE1; PD-1
  • Former name: SLEB2
  • Alias: systemic lupus erythematosus susceptibility 2


    • Overview of PDCD1 molecular targets


    CD279, also known as programmed cell death protein 1 (PD-1), is encoded by the PDCD1 gene. PD1 is a member of the immunoglobulin superfamily and belongs to the CD28 superfamily together with CD28, CTLA-4 and ICOS molecules. It is mainly expressed in activated CD4+T and CD8+T cells and B cells in monomeric form, and its ligands are B7-H1 and B7-DC. Studies have shown that enhancing the signal of PD-1 can downregulate the response of activated T and B cells in peripheral tissues, and play an important role in maintaining peripheral T and B cell tolerance.


    Human PDCD1 Molecular Target Information


    Molecule name: PDCD1, programmed cell death 1


    Alias:

    • CD279
    • hPD-1
    • hPD-l
    • hSLE1
    • PD-1
    • PD1
    • programmed cell death protein 1
    • SLEB2
    • systemic lupus erythematosus susceptibility 2

    Gene sequence:NCBI_Gene: 5133

    Protein sequence:UniProtKB: Q15116


    Human PDCD1 target molecular function (prediction)


    Involved in positive regulation of T cell apoptotic process. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. situ; liver disease (multiple); and tuberculosis (multiple).


    Mouse Pdcd1 molecular target information


    Molecule name: Pdcd1, programmed cell death 1


    Alias:

    • PD-1
    • Pdc1
    • programmed cell death


    Gene sequence:NCBI_Gene: 18566

    Protein sequence:


    Mouse Pdcd1 target molecular function (prediction)


    Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).


    Rat Pdcd1 molecular target information


    Molecule name: Pdcd1, programmed cell death 1

    Alias:

    • LOC102550808
    • LOC301626
    • programmed cell death protein 1
    • programmed cell death protein 1-like

    Gene sequence:NCBI_Gene: 301626

    Protein sequence:UniProtKB: D3ZIN8


    Rat Pdcd1 target molecular function (prediction)


    Predicted to be involved in negative regulation of immune response and positive regulation of T cell apoptotic process. Predicted to act upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in plasma membrane. Biomarker of anti-basement membrane glomerulonephritis; hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).