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Overview of APOA1 molecular target information


  • Molecular name: APOA1, apolipoprotein A1
  • Gene family: Apolipoproteins
  • Alias: apolipoprotein AI


    • Overview of APOA1 molecular targets


    Apolipoprotein A1 (Apo A1) is the major protein component of high-density lipoprotein (HDL) in plasma. Chylomicrons secreted by intestinal epithelial cells also contain Apo A1, but it is rapidly transferred to HDL in the blood. The protein has a specific role in lipid metabolism, facilitating fat efflux, including the transport of cholesterol from tissues to the liver for excretion. It is a cofactor for phosphatidylcholine cholesterol acyltransferase, responsible for the formation of most plasma cholesterol esters. Apo A1 is also a stabilizer of prostacyclin and may therefore have anticoagulant properties. Apo A1 is often used as a biomarker for predicting cardiovascular disease. The Apo B-100/Apo A1 ratio has been reported to be an effective predictive tool for predicting the risk of myocardial infarction compared to other lipid measurements. Deletions of the gene encoding Apo A1 have been associated with HDL defects, including Tangier disease, as well as systemic non-neuropathic amyloidosis.


    Human APOA1 Molecular Target Information


    Molecular name: APOA1, apolipoprotein A1


    Alias:

    • apo-AI
    • apo(a)
    • apoA-I
    • apolipoprotein AI
    • HPALP2
    • MGC117399

    Gene sequence:NCBI_Gene: 335

    Protein sequence:UniProtKB: P02647


    Human APOA1 target molecular function (prediction)


    Enables several functions, including amyloid-beta binding activity; cholesterol binding activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of Rho protein signal transduction. Acts upstream of or within cholesterol transport. Located in endocytic vesicle and extracellular space. Part of spherical high-density lipoprotein particle and very-low-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; liver disease (multiple); and neurodegenerative disease (multiple).


    Mouse Apoa1 molecular target information


    Molecular name: Apoa1, apolipoprotein AI


    Alternate names:

    • Alp-1
    • Apoa-1
    • brain protein 14
    • Brp-14
    • liver 20-30 thousand M.Wt protein 1
    • Ltw-1
    • Lvtw-1
    • Sep-1
    • Sep-2
    • Sep2
    • serum protein 1
    • serum protein 2


    Gene sequence:NCBI_Gene: 11806

    Protein sequence:


    Mouse Apoa1 target molecular function (prediction)


    Enables several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cholesterol biosynthetic process; cholesterol efflux; and regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in several structures, including adrenal gland; gonad; gut; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).


    Rat Apoa1 molecular target information


    Molecular name: Apoa1, apolipoprotein A1

    Alias:

    • apo-AI
    • apoA-I
    • apolipoprotein A-1
    • apolipoprotein AI
    • preproapolipoprotein AI

    Gene sequence:NCBI_Gene: 25081

    Protein sequence:UniProtKB: P04639


    Rat Apoa1 target molecular function (prediction)


    Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including lipid transport; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface; extracellular space; and nucleus. Part of discoidal high-density lipoprotein particle; diseases, including fatty liver disease (multiple); hypertension; major depressive disorder; ocular hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).