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MST1 molecular target information overview


  • Molecular name: MST1, macrophage stimulating 1
  • Alias: MSP; NF15S2
  • Former names: D3F15S2; HGFL; DNF15S2
  • Alias: hepatocyte growth factor-like


    • Overview of MST1 molecular targets


    Macrophage stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HGFL) and MST1, is a member of the HGF family of growth factors. MSP is secreted as an inactive single-chain precursor (pro-MSP) and is a ligand for the transmembrane receptor tyrosine kinase receptor (RON) (RON; also known as MST1R). Since its discovery, MSP has been shown to play a key role in regulating inflammation in peripheral tissues in a variety of disease models. Recent evidence also suggests that MSP has a beneficial role in regulating hepatic lipid and glucose metabolism, implicating MSP as a key regulator in maintaining metabolic homeostasis while inhibiting inflammatory processes. MSP induces macrophage and keratinocyte proliferation and osteoclast activation. It also inhibits LPS- or IFN-induced iNOS and IL-12 expression by macrophages and prevents apoptosis in epithelial cells isolated from the extracellular matrix.


    Human MST1 Molecular Target Information


    Molecule name: MST1, macrophage stimulating 1


    Alias:

    • D3F15S2
    • DNF15S2
    • hepatocyte growth factor-like protein
    • hepatocyte growth factor-like protein homolog
    • HGFL
    • macrophage stimulating 1 (hepatocyte growth factor-like)
    • macrophage stimulatory protein
    • macrophage-stimulating protein
    • MSP
    • NF15S2

    Gene sequence:NCBI_Gene: 4485

    Protein sequence:UniProtKB: P26927


    Human MST1 target molecular function (prediction)


    Enables receptor tyrosine kinase binding activity. Involved in histone H2A-S139 phosphorylation; negative regulation of gluconeogenesis; and regulation of cAMP-dependent protein kinase activity. Located in extracellular space. Part of collagen-containing extracellular matrix.


    Mouse Mst1 molecular target information


    Molecular name:Mst1, macrophage stimulating 1 (hepatocyte growth factor-like)


    Alias:

    • D3F15S2h
    • D9H3F15S2
    • DNA segment, Chr 9, human D3F15S2
    • DNF15S2h
    • hepatocyte growth factor-like
    • Hgfl


    Gene sequence:NCBI_Gene: 15235

    Protein sequence:


    Mouse Mst1 target molecular function (prediction)


    Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including embryo implantation; mammary duct terminal end bud growth; and positive regulation of mammary gland epithelial cell proliferation. Located in vacuole. Is expressed in esophagus epithelium; liver; liver parenchyma; pharynx epithelium; and stomach proventricular region epithelium. Orthologous to several human genes including MST1 (macrophage stimulating 1).


    Rat Mst1 molecular target information


    Molecular name: Mst1, macrophage stimulating 1

    Alias:

    • D8h3f15s2
    • E2F transcription factor 2
    • E2F2
    • hepatocyte growth factor-like protein
    • Macrophage stimulating 1 (hepatocyte growth factor-like)

    Gene sequence:NCBI_Gene: 24566

    Protein sequence:


    Rat Mst1 target molecular function (prediction)


    Enables enzyme binding activity. Involved in cellular response to hypoxia; flagellated sperm motility; and spermatogenesis. Located in cytoplasm. Orthologous to several human genes including MST1 (macrophage stimulating 1).