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CCL13 molecular target information overview


  • Molecular name: CCL13, CC motif chemokine ligand 13
  • Gene family: Chemokine ligands
  • Alias: MCP-4; NCC-1; SCYL1; CKb10; MGC17134
  • Former name: SCYA13
  • Alias: small inducible cytokine subfamily A (Cys-Cys), member 13; chemokine (CC motif) ligand 13


    • CCL13 molecular target review


    Chemokine CC ligand 13 (CCL13), also known as monocyte chemoattractant protein 4 (MCP-4), is a small molecule cytokine in the CC chemokine family. Its gene is located on human chromosome 17 in a large cluster of other CC chemokines. CCL13 attracts monocytes, eosinophils, T lymphocytes, and basophils by binding to cell surface G protein-linked chemokine receptors such as CCR2, CCR3, and CCR5. CCL13 activity is involved in allergic reactions such as asthma. Inflammatory cytokines such as IL-1 and TNF-α can induce CCL13.


    Human CCL13 Molecular Target Information


    Molecular name: CCL13, CC motif chemokine ligand 13


    Alias:

    • CC motif chemokine 13
    • chemokine (CC motif) ligand 13
    • CK-beta-10
    • CKb10
    • MCP-4
    • MGC17134
    • monocyte chemoattractant protein 4
    • monocyte chemotactic protein 4
    • NCC-1
    • NCC1
    • new CC chemokine 1
    • SCYA13
    • SCYL1
    • small inducible cytokine subfamily A (Cys-Cys), member 13
    • small-inducible cytokine A13

    Gene sequence:NCBI_Gene: 6357

    Protein sequence:UniProtKB: Q99616


    Human CCL13 target molecular function (prediction)


    Enables chemokine activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; eosinophil chemotaxis; and regulation of cell shape. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in multiple sclerosis.


    Mouse Ccl11 molecular target information


    Molecular name: Ccl11, chemokine (CC motif) ligand 11


    Alternate names:

    • eotaxin
    • Scya11
    • small inducible cytokine A11


    Gene sequence:NCBI_Gene: 20292

    Protein sequence:


    Mouse Ccl11 target molecular function (prediction)


    Predicted to enable CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; endocardial lining; liver parenchyma; liver vasculature; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (CC motif chemokine ligand 11).


    Rat Ccl12 molecular target information


    Molecular name: Ccl12, chemokine (CC motif) ligand 12

    Alias:

    • LOC287562
    • MCP-5
    • monocyte chemotactic protein 5

    Gene sequence:NCBI_Gene: 287562

    Protein sequence:UniProtKB: D4ABS1


    Rat Ccl12 target molecular function (prediction)


    Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in negative regulation of leukocyte proliferation and positive regulation of leukocyte migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to several human genes including CCL8 (CC motif chemokine ligand 8).