FST molecular target information overview
Overview of FST molecular targets
Follistatin, also known as activin binding protein, is encoded by the FST gene in humans. Follistatin is an autocrine glycoprotein expressed in almost all tissues of higher animals. Follistatin is produced by follicular stellate cells (FS) in the anterior pituitary. Its basic function is to bind and bioneutralize members of the TGF-β superfamily. Follicle-stimulating hormone is currently being studied as an antagonist of myostatin in regulating muscle growth in mice. Animal models of spinal muscular atrophy have shown that increasing follistatin levels by increasing muscle mass in certain core muscle groups can increase life expectancy. In addition, the relationship between follistatin and polycystic ovary syndrome is also being studied.
Human FST Molecular Target Information
Molecular name: FST, follistatin
Alias:
- activin-binding protein
- follistatin isoform FST317
- FS
Gene sequence:NCBI_Gene: 10468
Protein sequence:UniProtKB: P19883
Human FST target molecular function (prediction)
Enables activin binding activity and activin receptor antagonist activity. Involved in hematopoietic progenitor cell differentiation; negative regulation of activin receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of hair follicle development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in polycystic ovary syndrome.
Mouse Fst molecular target information
Molecular name: Fst, follistatin
Alias:
- None
Gene sequence:NCBI_Gene: 14313
Protein sequence:
Mouse Fst target molecular function (prediction)
Predicted to enable activin binding activity; activin receptor antagonist activity; and heparan sulfate proteoglycan binding activity. Acts upstream of or within several processes, including BMP signaling pathway; animal organ development; and keratinocyte proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and genitourinary system. Used to study lethal restrictive derm Humanopathy. Ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin).
Rat Fst molecular target information
Molecular name: Fst, follistatin
Alias:
- activin-binding protein
- FOL1
- follistatin-A
- FS
- Fst-288
- LOC686745
- RATFOL1
- similar to follistatin
Gene sequence:NCBI_Gene: 24373
Protein sequence:UniProtKB: P21674
Rat Fst target molecular function (prediction)
Enables heparan sulfate proteoglycan binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; keratinocyte proliferation; Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin).