Overview of PLAUR molecular target information
Overview of PLAUR molecular targets
Urokinase plasminogen activator receptor (uPAR) is a cell surface receptor that binds urokinase plasminogen activator (uPA) with high affinity, thereby promoting the activation of plasminogen cells. It is a multidomain glycoprotein anchored to the cell membrane via GPI and was originally identified as a saturated binding site for urokinase on the cell surface. uPAR binds urokinase, limiting the activation of plasminogen closest to the cell membrane periphery. In addition to the main ligand urokinase, uPAR also interacts with other proteins, among which vitronectin is a uPAR-related protein and an integrin family membrane protein. uPAR is part of the plasminogen activator system and, in a healthy body, participates in tissue remodeling such as breast involution and wound healing. uPAR is involved in other cancer-related processes such as cell migration, cell cycle regulation, and cell adhesion.
Human PLAUR Molecular Target Information
Molecular name:PLAUR, plasminogen activator, urokinase receptor
Alias:
- CD87
- monocyte activation antigen Mo3
- U-PAR
- u-plasminogen activator receptor form 2
- UPAR
- URKR
- urokinase plasminogen activator surface receptor
- urokinase-type plasminogen activator (uPA) receptor
Gene sequence:NCBI_Gene: 5329
Protein sequence: UniProtKB: Q03405
Human PLAUR target molecular function (prediction)
Enables enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Located in cell surface and plasma membrane. Implicated in rheumatoid arthritis. Biomarker of several diseases, including Lyme disease; cardiovascular system disease (multiple); end stage renal disease; hepatitis B;
Mouse Plaur Molecular Target Information
Molecular name:Plaur, plasminogen activator, urokinase receptor
Alias:
- Cd87
- u-PAR
- uPAR
- urokinase-type plasminogen activator receptor
Gene sequence:NCBI_Gene: 18793
Protein sequence:
Mouse Plaur Target Molecular Function (Prediction)
Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Is integral component of plasma membrane. Is expressed in several structures, including decidua; early conceptus; and spleen. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor).
Rat Plaur Molecular Target Information
Molecular name:Plaur, plasminogen activator, urokinase receptor
Alias:
- Par
- plasminogen activator urokinase receptor 3
- plasminogen activator, urokinase receptor 3
- Plaur3
- U-PAR
- uPAR
- uPAR-2
- uPAR-3
- urinary plasminogen activator receptor 2
- urinary plasminogen activator receptor 3
- urokinase plasminogen activator receptor
- urokinase plasminogen activator surface receptor
Gene sequence:NCBI_Gene: 50692
Protein sequence:
Rat Plaur Target Molecular Function (Prediction)
Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including epithelial cell differentiation involved in prostate gland development; skeletal muscle tissue regeneration; and spermatogenesis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor).