Blog

CXCL3 molecular target information overview


  • Molecular name: CXCL3, CXC motif chemokine ligand 3
  • Gene family: Chemokine ligands
  • Other names: SCYB3; GROg; MIP-2b; CINC-2b
  • Former name: GRO3
  • Alias: GRO3 oncogene; chemokine (CXC motif) ligand 3


    • CXCL3 molecular target review


    CXCL1, CXCL2, and CXCL3, known as GRO alpha, GRO beta (MIP-2 alpha), and GRO gamma (MIP-2 beta), respectively, are members of the CXC subfamily of chemokines. Mature CXCL1/2/3 proteins bind to the B-type IL-8 receptor with high affinity and are potent neutrophil attractants and activators. Chemokines primarily act on leukocytes to regulate their trafficking. In general, members of the chemokine alpha family preferentially attract and activate neutrophils. Recombinant human growth-regulated oncogene gamma (GRO-γ) is a 7.9 kDa protein composed of 73 amino acids, including the common “ELR” motif of the CXC chemokine family that binds to CXCR1 or CXCR2. Mature human CXCL3 (aa 35-107) has 70% and 74% amino acid sequence homology with mouse and rat CXCL3, respectively. CXCL3 plays a key role in monocyte migration and adhesion through its interaction with the CXCR2 receptor.


    Human CXCL3 Molecular Target Information


    Molecular name: CXCL3, CXC motif chemokine ligand 3


    Alias:

    • CXC motif chemokine 3
    • chemokine (CXC motif) ligand 3
    • CINC-2b
    • GRO-gamma
    • GRO-gamma(1-73)
    • GRO3
    • GRO3 oncogene
    • GROg
    • -growthregulated protein gamma
    • macrophage inflammatory protein 2-beta
    • melanoma growth stimulatory activity gamma
    • MGSA gamma
    • MIP-2b
    • MIP2-beta
    • MIP2B
    • SCYB3

    Gene sequence:NCBI_Gene: 2921

    Protein sequence:UniProtKB: P19876


    Human CXCL3 target molecular function (prediction)


    Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Located in extracellular space.


    Mouse Cxcl3 molecular target information


    Molecular name: Cxcl3, chemokine (CXC motif) ligand 3


    Alias:

    • Dcip1
    • gene model 1960, (NCBI)
    • Gm1960


    Gene sequence:NCBI_Gene: 330122

    Protein sequence:


    Mouse Cxcl3 target molecular function (prediction)


    Enables chemokine activity. Involved in neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in genitourinary system; gut; and thymus. Orthologous to human CXCL1 (CXC motif chemokine ligand 1); CXCL2 (CXC motif chemokine ligand 2); chemokine ligand 3).


    Rat Cxcl3 molecular target information


    Molecular name: Cxcl3, CXC motif chemokine ligand 3

    Alias:

    • CXC motif chemokine 3
    • chemokine (CXC motif) ligand 3
    • Cinc-2
    • Cinc2
    • cytokine-induced neutrophil chemoattractant 2
    • cytokine-induced neutrophil chemoattractant-2
    • gene model 1960, (NCBI)
    • Gm1960
    • macrophage inflammatory protein 2-alpha/beta
    • MIP2-alpha/beta

    Gene sequence:NCBI_Gene: 171551

    Protein sequence:UniProtKB: Q10746


    Rat Cxcl3 target molecular function (prediction)


    Enables chemokine activity. Involved in several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Biomarker of Coronavirus infectious disease and bacterial pneumonia. Orthologous to human CXCL1 (CXC motif chemokine ligand 1); CXCL2 (CXC motif chemokine ligand 2); and CXCL3 (CXC motif chemokine ligand 3).