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IGFBP1 molecular target information overview


  • Molecular name: IGFBP1, insulin like growth factor binding protein 1
  • Gene family: Insulin like growth factor binding proteins
  • Alias: IGF-BP25; AFBP; hIGFBP-1; PP12
  • Previous name: IBP1
  • Alias: placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associated endometrial globulin; growth hormone independent-binding protein; binding protein-28; binding protein-26; binding protein-25; IGF-binding protein 1; insulin-like growth factor binding protein 1


    • Review of IGFBP1 molecular targets


    Insulin-like growth factor-binding protein 1 (IGFBP-1), also known as placental protein 12 (PP12), is a protein encoded by the IGFBP1 gene. It binds to insulin-like growth factors (IGFs) I and II and circulates in the plasma. Such binding prolongs the half-life of IGFs and alters their interaction with cell surface receptors. IGFBPs can regulate the biological activity of IGF proteins. Post-transcriptional modifications of IGFBPs (such as glycosylation, phosphorylation, and proteolysis) can change the affinity of the binding protein to IGF. High concentrations of IGFBP-1 may be a marker of a catabolic state, and studies have shown that women with high concentrations of IGFBP-1 have less muscle mass. A higher IGFBP-1/IGF-1 ratio in the serum of patients with nasopharyngeal carcinoma is significantly associated with a poor prognosis. It has been reported that local IGFBP1 levels have an effect on the formation of coronary artery plaques.


    Human IGFBP1 Molecular Target Information


    Molecular name:IGFBP1, insulin like growth factor binding protein 1


    Alias:

    • AFBP
    • alpha-pregnancy-associated endometrial globulin
    • amniotic fluid binding protein
    • binding protein-25
    • binding protein-26
    • binding protein-28
    • growth hormone independent-binding protein
    • hIGFBP-1
    • IBP-1
    • IBP1
    • IGF-binding protein 1
    • IGF-BP25
    • IGFBP-1
    • insulin-like growth factor binding protein 1
    • insulin-like growth factor-binding protein 1
    • placental protein 12
    • PP12

    Gene sequence:NCBI_Gene: 3484

    Protein sequence: UniProtKB: P08833


    Human IGFBP1 target molecular function (prediction)


    Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.


    Mouse Igfbp1 molecular target information


    Molecular name:Igfbp1, insulin-like growth factor binding protein 1


    Alias:

    • IGFBP-1


    Gene sequence:NCBI_Gene: 16006

    Protein sequence:


    Mouse Igfbp1 target molecular function (prediction)


    Enables insulin-like growth factor binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including blastocyst; early embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).


    Rat Igfbp1 molecular target information


    Molecular name:Igfbp1, insulin-like growth factor binding protein 1

    Alias:

    • IBP-1
    • IBP1
    • IGF-binding protein 1
    • IGF-BP25
    • IGFBA
    • IGFBP-1
    • insulin-like growth factor-binding protein 1
    • placental protein 12

    Gene sequence:NCBI_Gene: 25685

    Protein sequence:UniProtKB: P21743


    Rat Igfbp1 target molecular function (prediction)


    Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell growth; and tissue regeneration. Located in extracellular space. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).