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TIE1 molecular target information overview


  • Molecular name: TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
  • Gene family: Receptor tyrosine kinases; Fibronectin type III domain containing; Immunoglobulin like domain containing
  • Alias: JTK14
  • Previous name: TIE
  • Alias:tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1


    • Overview of TIE1 molecular targets


    The tyrosine protein kinase receptor Tie1 is a single-pass transmembrane type I membrane protein that belongs to the protein kinase superfamily, the tyrosine protein kinase family, and the Tie subfamily. Tie1 has three EGF-like domains, three fibronectin type III domains, two immunoglobulin-like C2-type domains, and a protein kinase domain. Tie1 is a cell surface protein that is exclusively expressed in endothelial cells, however, studies have shown that it can also be expressed in immature hematopoietic cells and platelets. During the capillary emergence stage of vascular development, Tie1 is essential for the survival and growth of microvascular endothelial cells. Tie1 upregulates cell adhesion molecules VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Tie1 expression can enhance the adhesion of monocyte-derived immune cells to endothelial cells. Tie1 has a pro-inflammatory effect and plays an important role in endothelial inflammatory diseases such as atherosclerosis.


    Human TIE1 Molecular Target Information


    Molecular name:TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1


    Alias:

    • JTK14
    • LMPHM11
    • receptor tyrosine kinase
    • soluble TIE1 variant 1
    • soluble TIE1 variant 2
    • soluble TIE1 variant 3
    • soluble TIE1 variant 4
    • soluble TIE1 variant 5
    • TIE
    • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
    • tyrosine kinase with immunoglobulin-like and EGF-like domains 1
    • tyrosine-protein kinase receptor Tie-1

    Gene sequence:NCBI_Gene: 7075

    Protein sequence:UniProtKB: P35590


    Human TIE1 target molecular function (prediction)


    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of angiogenesis; and positive regulation of kinase activity. Predicted to act upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Predicted to be located in plasma membrane. Implicated in hereditary lymphedema.


    Mouse Tie1 molecular target information


    Molecular name:Tie1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1


    Alias:

    • D430008P04Rik
    • RIKEN cDNA D430008P04 gene
    • TIE
    • tie-1


    Gene sequence:NCBI_Gene: 21846

    Protein sequence:


    Mouse Tie1 target molecular function (prediction)


    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).


    Rat Tie1 molecular target information


    Molecular name:Tie1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1

    Also known as:

    • tyrosine kinase receptor 1
    • tyrosine-protein kinase receptor Tie-1

    Gene sequence:NCBI_Gene: 89806

    Protein sequence:UniProtKB: B5DFD6


    Rat Tie1 target molecular function (prediction)


    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in vasculogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex.