LYVE1 Molecular Target Information Overview
Overview of LYVE1 molecular targets
Lymphatic endothelial hyaluronic acid receptor-1 (LYVE-1) is a lymphatic endothelial-specific marker that is specifically expressed in lymphatic endothelial cells and evenly distributed on the basal and luminal surfaces of lymphatic endothelial cells. It is widely used to promote the research in the field of tumor lymphatic metastasis. In recent years, the biological function of LYVE-1 itself and its role in the field of tumor metastasis have become one of the research hotspots of tumor metastasis. Elucidating the mechanism of action of LYVE-1 in tumor lymphatic metastasis is of great significance for establishing new methods for tumor treatment.
Human LYVE1 Molecular Target Information
Molecular name:LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
Alias:
- cell surface retention sequence binding protein-1
- cell surface retention sequence-binding protein 1
- CRSBP-1
- extracellular link domain containing 1
- extracellular link domain-containing 1
- extracellular link domain-containing protein 1
- HAR
- hyaluronic acid receptor
- lymphatic vessel endothelial hyaluronic acid receptor 1
- LYVE-1
- XLKD1
Gene sequence:NCBI_Gene: 10894
Protein sequence:UniProtKB: Q9Y5Y7
Human LYVE1 target molecular function (prediction)
Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to be involved in anatomical structure morphogenesis; cell-matrix adhesion; and response to wounding. Predicted to act upstream of or within glycosaminoglycan catabolic process. Located in extracellular exosome.
Mouse Lyve1 molecular target information
Molecular name:Lyve1, lymphatic vessel endothelial hyaluronan receptor 1
Alternate names:
- 1200012G08Rik
- extra cellular link domain-containing 1
- lymphatic vessel endothelial HA receptor-1
- Lyve-1
- RIKEN cDNA 1200012G08 gene
- Xlkd1
Gene sequence:NCBI_Gene: 114332
Protein sequence:
Mouse Lyve1 target molecular function (prediction)
Enables hyaluronic acid binding activity and transmembrane signaling receptor activity. Acts upstream of or within glycosaminoglycan catabolic process. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; gut; hemolymphoid system; meninges; and metanephros. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1).
Rat Lyve1 molecular target information
Molecular name:Lyve1, lymphatic vessel endothelial hyaluronan receptor 1
Alias:
- extra cellular link domain-containing 1
- extracellular link domain-containing 1
- LOC293186
- lymphatic vessel endothelial hyaluronic acid receptor 1
- Xlkd1
Gene sequence:NCBI_Gene: 293186
Protein sequence:UniProtKB: D3ZD19
Rat Lyve1 target molecular function (prediction)
Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within glycosaminoglycan catabolic process. Predicted to be located in cell periphery. Predicted to be active in plasma membrane. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1).