Overview of FGF1 molecular target information
Overview of FGF1 molecular targets
Fibroblast growth factor acidic (FGF acidic), also known as FGF-1, ECGF and HBGF-1, is a secreted mitogen that stimulates proliferation of all cells of mesodermal origin and cells of neuroectodermal, ectodermal and endodermal origin. It plays a role in development, regeneration and angiogenesis. Internalized FGF acidic can be translocated to the cytoplasm with the help of Hsp90 and then migrate to the nucleus via its two nuclear localization signals. Phosphorylation of FGF acidic by PKCδ triggers active export to the cytoplasm, where it is dephosphorylated and degraded. Intracellularly, FGF acidic acts as a survival factor by inhibiting p53 activity and pro-apoptotic signaling.
Human FGF1 Molecular Target Information
Molecular name:FGF1, fibroblast growth factor 1
Alias:
- acidic fibroblast growth factor
- AFGF
- beta-endothelial cell growth factor
- ECGF
- ECGF-beta
- ECGFA
- ECGFB
- endothelial cell growth factor
- endothelial cell growth factor, alpha
- endothelial cell growth factor, beta
- FGF-1
- FGF-alpha
- FGFA
- fibroblast growth factor 1 (acidic)
- GLIO703
- HBGF-1
- HBGF1
- heparin-binding growth factor 1
Gene sequence:NCBI_Gene: 2246
Protein sequence:UniProtKB: P05230
Human FGF1 target molecular function (prediction)
Enables S100 protein binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of biosynthetic process; and regulation of endothelial cell migration. Located in cytosol; extracellular space; and nucleoplasm. Implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Biomarker of Alzheimer's disease; endometrial cancer; leiomyoma; ovarian cancer; and transitional cell carcinoma.
Mouse Fgf1 molecular target information
Molecular name:Fgf1, fibroblast growth factor 1
Alias:
- Fgf-1
- Fgfa
- fibroblast growth factor 1 (acidic)
- fibroblast growth factor, acidic
Gene sequence:NCBI_Gene: 14164
Protein sequence:
- UniprotKB: P61148
- UniprotKB: A0A494BBG9
- UniprotKB: D3Z192
- UniprotKB: D3Z6E2
- UniprotKB: D3Z6H1
- UniprotKB: D6RCX9
- UniprotKB: O54837
- UniprotKB: Q6ZWS1
Mouse Fgf1 target molecular function (prediction)
Predicted to enable several functions, including Hsp70 protein binding activity; S100 protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including organ induction; positive regulation of epithelial cell proliferation; and positive regulation of nitrogen compound metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory. organ Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1).
Rat Fgf1 molecular target information
Molecular name:Fgf1, fibroblast growth factor 1
Alias:
- acidic fibroblast growth factor
- aFGF
- FGF-1
- Fgf2b
- fibroblast growth factor 1 (acidic)
- Fibroblast growth factor 1 (heparin binding)
- fibroblast growth factor 2b
- HBGF-1
- HBGF1
- heparin-binding growth factor 1
Gene sequence:NCBI_Gene: 25317
Protein sequence:
Rat Fgf1 target molecular function (prediction)
Enables Hsp70 protein binding activity and growth factor activity. Involved in positive regulation of hepatocyte proliferation. Located in cytoplasm and nucleolus. Used to study brain ischemia. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia;