Overview of NGF molecular target information
Overview of NGF molecular targets
Nerve growth factor (NGF) is a neuropeptide that is primarily involved in regulating the growth, proliferation, and survival of certain target neurons. When expressed, NGF initially exists as a 7S, 130 kDa complex consisting of three proteins: α-NGF, β-NGF, and γ-NGF (2:1:2 ratio). "Nerve growth factor" usually refers to the 2.5S, 26 kDa β-subunit protein. The β-subunit is the only biologically active component of the 7SNGF complex (e.g., as a signaling molecule). NGF plays an important role in both innate and acquired immunity. Studies have shown that NGF circulates in the body through plasma and is important for overall homeostasis. NGF promotes myelin repair and is also involved in a variety of psychiatric disorders, such as Alzheimer's disease, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Dysregulation of NGF signaling is associated with Alzheimer's disease. Similarly, NGF plays a role in many cardiovascular diseases, such as coronary atherosclerosis, obesity, type 2 diabetes, and metabolic syndrome. NGF can also promote wound healing.
Human NGF molecular target information
Molecular name:NGF, nerve growth factor
Alias:
- beta-nerve growth factor
- Beta-NGF
- HSAN5
- MGC161426
- MGC161428
- nerve growth factor (beta polypeptide)
- nerve growth factor, beta polypeptide
- nerve growth factor, beta subunit
- NGFB
- pro-nerve growth factor long
Gene sequence:NCBI_Gene: 4803
Protein sequence: UniProtKB: P01138
Human NGF target molecular function (prediction)
Enables peptidase regulator activity and signaling receptor binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors; neuron apoptotic process; and positive regulation of macromolecule metabolic process. Acts upstream of or within neuron projection morphogenesis. Predicted to be located in neuron projection terminus. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Biomarker of several diseases, including artery disease (multiple); interstitial cystitis; lung disease (multiple); neurogenic bladder; and obstructive sleep apnea.
Mouse Ngf molecular target information
Molecular name:Ngf, nerve growth factor
Alternate names:
- nerve growth factor, beta
- Ngfb
Gene sequence:NCBI_Gene: 18049
Protein sequence:
Mouse Ngf target molecular function (prediction)
Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell projection organization; and positive regulation of macromolecule metabolic process. Located in neuron projection terminus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).
Rat Ngf molecular target information
Molecular name:Ngf, nerve growth factor
Synonyms:
- beta-nerve growth factor
- beta-NGF
- nerve growth factor (beta polypeptide)
- nerve growth factor, beta
- nerve growth factor, beta (mapped)
- Ngfb
- Ngfb_mapped
- pro-nerve growth factor long
Gene sequence:NCBI_Gene: 310738
Protein sequence:
Rat Ngf target molecular function (prediction)
Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor).