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EFNA1 molecular target information overview


  • Molecular name: EFNA1, ephrin A1
  • Gene family: Ephrins
  • Alias: LERK1; ECKLG; GMAN
  • Previous names: TNFAIP4; ligand 1; Tumor necrosis factor alpha-induced protein 4; gastric cancer metastasis associated long noncoding RNA; ephrin-A1


    • Overview of EFNA1 molecular targets


    Ephrin-A1, also known as EFNA1, is encoded in humans by the EFNA1 gene, which encodes a member of the Eph family. Ephrins and Eph-related receptors constitute the largest subfamily of receptor tyrosine kinases and are involved in regulating the development of the nervous and hematopoietic systems. Based on their structural and sequence relationships, ephrins can be divided into ephrin-A (EFNA) and ephrin-B (EFNB) classes. Ephrin-A ligands bind to EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage. Ephrin-B ligands bind to EphB receptors and are anchored to the plasma membrane via a transmembrane domain. Ephrin-A1 and one of its receptors, EphA2, are expressed in xenograft endothelial cells and tumor cells and may play a role in human cancers, in part by affecting tumor neovascularization.


    Human EFNA1 Molecular Target Information


    Molecular name: EFNA1, ephrin A1


    Alias:

    • B61
    • ECKLG
    • EFL1
    • eph-related receptor tyrosine kinase ligand 1
    • ephrin-A1
    • EPLG1
    • gastric cancer metastasis associated long noncoding RNA
    • GMAN
    • immediate early response protein B61
    • LERK-1
    • LERK1
    • ligand of eph-related kinase 1
    • TNF alpha-induced protein 4
    • TNFAIP4
    • tumor necrosis factor alpha-induced protein 4
    • tumor necrosis factor, alpha-induced protein 4

    Gene sequence:NCBI_Gene: 1942

    Protein sequence:UniProtKB: P20827


    Human EFNA1 target molecular function (prediction)


    Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein stabilization; and regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Predicted to be anchored component of plasma membrane.


    Mouse Efna1 molecular target information


    Molecule name: Efna1, ephrin A1


    Alternate names:

    • AI325262
    • B61
    • EFL-1
    • eph-related receptor tyrosine kinase ligand 1
    • Epl1
    • Eplg1
    • expressed sequence AI325262
    • LERK-1
    • Lerk1


    Gene sequence:NCBI_Gene: 13636

    Protein sequence:


    Mouse Efna1 target molecular function (prediction)


    Acts upstream of or within several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of MAPK cascade. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1).


    Rat Efna1 molecular target information


    Molecule name: Efna1, ephrin A1

    Alias:

    • B61
    • EPH-related receptor tyrosine kinase ligand 1
    • ephrin-A1
    • immediate early response protein B61
    • LERK-1

    Gene sequence:NCBI_Gene: 94268

    Protein sequence:UniProtKB: P97553


    Rat Efna1 target molecular function (prediction)


    Predicted to enable ephrin receptor binding activity. Predicted to be involved in several processes, including cell morphogenesis involved in differentiation; heart valve morphogenesis; and regulation of protein metabolism process. Predicted to act upstream of or within several processes, including negative regulation of thymocyte apoptotic process; nervous system development; and regulation of MAPK cascade. Orthologous to human EFNA1 (ephrin A1).