CCL16 molecular target information overview
CCL16 molecular target review
Chemokine CC ligand 16 (CCL16) is a small molecule cytokine in the CC chemokine family, also known as NCC-4, liver-expressed chemokine (LEC), and lymphocyte and monocyte chemoattractant (LMC). This chemokine is expressed by the liver, thymus, and spleen and is chemotactic for monocytes and lymphocytes. Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ, and bacterial lipopolysaccharide. In addition, CCL16 triggers its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5, and CCR8. This chemokine inhibits the rapid proliferation of bone marrow precursor cells.
Human CCL16 Molecular Target Information
Molecular name: CCL16, CC motif chemokine ligand 16
Alias:
- CC motif chemokine 16
- chemokine (CC motif) ligand 16
- chemokine CC-4
- chemokine LEC
- CKb12
- HCC-4
- IL-10-inducible chemokine
- ILINCK
- LCC-1
- LEC
- liver CC chemokine-1
- liver-expressed chemokine
- LMC
- lymphocyte and monocyte chemoattractant
- MGC117051
- monotactin-1
- Mtn-1
- NCC-4
- NCC4
- new CC chemokine 4
- SCYA16
- SCYL4
- small inducible cytokine subfamily A (Cys-Cys), member 16
- small-inducible cytokine A16
Gene sequence:NCBI_Gene: 6360
Protein sequence: UniProtKB: O15467
Human CCL16 target molecular function (prediction)
Enables chemoattractant activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in extracellular region. Predicted to be active in extracellular space.