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LEPR molecular target information overview


  • Molecular name: LEPR, leptin receptor
  • Gene family: CD molecules; Immunoglobulin like domain containing
  • Other names: OBR; CD295


    • Overview of LEPR molecular targets


    The leptin receptor (Leptin R), also known as OB-R or CD295, is encoded by the LEPR gene in humans. It functions as a receptor for the adipocyte-specific hormone leptin. Leptin binds to its receptor and regulates adipose tissue mass through its hypothalamic effects on hunger and energy expenditure. Mutations in the leptin receptor are associated with diabetes and increased susceptibility to infection with Entamoeba histolytica.


    Human LEPR molecular target information


    Molecular name: LEPR, leptin receptor


    Alias:

    • CD295
    • DKFZp686B1731
    • huB219
    • LEP-R
    • LEPRD
    • OB receptor
    • OB-R
    • OBR

    Gene sequence:NCBI_Gene: 3953

    Protein sequence: UniProtKB: P48357


    Human LEPR target molecular function (prediction)


    Enables identical protein binding activity and leptin receptor activity. Involved in several processes, including angiogenesis; leptin-mediated signaling pathway; and negative regulation of autophagy. Part of receptor complex. Implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Biomarker of arteriosclerosis; chronic obstructive pulmonary disease; human immunodeficiency virus infectious disease; liver disease (multiple); and sleep apnea.


    Mouse Lepr molecular target information


    Molecular name:Lepr, leptin receptor


    Alias:

    • db
    • diabetes
    • Leprb
    • LEPROT
    • leptin receptor gene-related protein
    • Modb1
    • OB-RGRP
    • obese-like
    • obl
    • Obr


    Gene sequence:NCBI_Gene: 16847

    Protein sequence:


    Mouse Lepr target molecular function (prediction)


    Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).


    Rat Lepr molecular target information


    Molecular name:Lepr, leptin receptor

    Alias:

    • Fa
    • LEP-R
    • Leptin receptor (fatty)
    • OB receptor
    • OB-R

    Gene sequence:NCBI_Gene: 24536

    Protein sequence:


    Rat Lepr target molecular function (prediction)


    Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Located in extracellular space and plasma membrane. Used to study several diseases, including chronic kidney disease; glucose metabolism disease (multiple); obesity; pancreatitis; including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).