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AGT molecular target information overview


  • Molecular name: AGT, angiotensinogen
  • Gene family: Serpin peptidase inhibitors; Neuropeptides
  • Former name: SERPINA8
  • Alias: alpha-1 antiproteinase, antitrypsin; serpin peptidase inhibitor, clade A, member 8


    • AGT molecular target review


    Angiotensinogen (AGT), also known as SerpinA8, is a member of the serine protease inhibitor family. AGT is an alpha-2-globulin that is constitutively produced by the liver and released into the circulation. AGT is an essential component of the renin-angiotensin system and is an effective regulator of blood pressure. AGT can be cleaved into three chains: angiotensin-1, angiotensin-2, and angiotensin-3. The absence of AGT is associated with essential hypertension and renal tubular dysgenesis. Several serine protease inhibitors (antithrombin, maspin, pigment epithelium-derived factor, and kallistatin) have recently been shown to have antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. AGT and its renin cleavage products are also inhibitors of angiogenesis within the range of plasma concentrations observed in vitro and in vivo.


    Human AGT molecular target information


    Molecular name: AGT, angiotensinogen


    Alias:

    • alpha-1 antiproteinase, antitrypsin
    • angiotensin I
    • angiotensin II
    • angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8)
    • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    • ANHU
    • fetal-liver predominant transporter 1
    • FLJ92595
    • FLJ97926
    • hFLT1
    • pre-angiotensinogen
    • serine (or cysteine) proteinase inhibitor
    • serpin A8
    • serpin peptidase inhibitor, clade A, member 8
    • SERPINA8

    Gene sequence:NCBI_Gene: 183

    Protein sequence:UniProtKB: P01019


    Human AGT target molecular function (prediction)


    Enables angiotensin receptor binding activity; receptor ligand activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; systemic scleroderma (multiple); and type 2 diabetes mellitus.


    Mouse Agt molecular target information


    Molecular name:Agt, angiotensinogen (serpin peptidase inhibitor, clade A, member 8)


    Alternate names:

    • AI265500
    • angiotensin precursor
    • Aogen
    • expressed sequence AI265500
    • Serpina8


    Gene sequence:NCBI_Gene: 11606

    Protein sequence:


    Mouse Agt target molecular function (prediction)


    Enables type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).


    Rat Agt molecular target information


    Molecular name: Agt, angiotensinogen

    Alias:

    • Ang
    • AngII
    • angiotensin II
    • angiotensinogen (PAT)
    • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    • ANRT
    • MGC105326
    • PAT
    • serpin A8

    Gene sequence:NCBI_Gene: 24179

    Protein sequence: UniProtKB: P01015


    Rat Agt target molecular function (prediction)


    Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).