Overview of SELP Molecular Target Information
Overview of SELP molecular targets
CD62P is a 140kDa transmembrane glycoprotein also known as P-Selectin. P-Selectin is stored in the α-granules of platelets and the Weibel-Palade bodies of endothelial cells and is rapidly transported to the plasma membrane upon activation. In inflammatory responses, P-Selectin is thought to mediate the initial adhesion interaction of neutrophils and monocytes to the endothelium; in hemostasis, activated platelets interact with neutrophils and monocytes.
Human SELP molecular target information
Molecule name: SELP, selectin P
Alias:
- CD62
- CD62 antigen-like family member P
- CD62P
- FLJ45155
- GMP-140
- GMP140
- granule membrane protein 140
- granule membrane protein 140kDa
- granulocyte membrane protein
- GRMP
- LECAM3
- leukocyte-endothelial cell adhesion molecule 3
- P-selectin
- PADGEM
- platelet activation dependent granule-external membrane protein
- platelet alpha-granule membrane protein
- PSEL
- selectin P (granule membrane protein 140kDa, antigen CD62)
Gene sequence:NCBI_Gene: 6403
Protein sequence:UniProtKB: P16109
Human SELP target molecular function (prediction)
Enables several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-mediated signaling using intracellular calcium source; and leukocyte tethering or rolling. Located in external side of plasma membrane; extracellular space; and platelet alpha granule membrane. Is integral component of plasma membrane. Implicated in atopic dermatitis and myocardial infarction. Biomarker of several diseases, including Kawasaki disease; autoimmune disease (multiple); coronary artery disease (multiple); obesity; and type 2 diabetes mellitus.
Mouse Selp molecular target information
Molecule name: Selp, selectin, platelet
Alias:
- CD62P
- granulocyte membrane protein
- Grmp
- P-selectin
Gene sequence:NCBI_Gene: 20344
Protein sequence:
Mouse Selp target molecular function (prediction)
Enables calcium-dependent protein binding activity and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling and positive regulation of platelet activation. Acts upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).
Rat Selp molecular target information
Molecule name: Selp, selectin P
Alias:
- CD62 antigen-like family member P
- GMP-140
- granule membrane protein 140
- LECAM3
- leukocyte-endothelial cell adhesion molecule 3
- MGC124632
- P-selectin
- PADGEM
- platelet activation dependent granule-external membrane protein
- PSELECT
- Selectin platelet
- selectin, platelet
Gene sequence:NCBI_Gene: 25651
Protein sequence:
Rat Selp target molecular function (prediction)
Predicted to enable several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including leukocyte migration; regulation of cellular extravasation; and response to lipopolysaccharide. Located in external side of plasma membrane and extracellular space. Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).