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CCL5 molecular target information overview


  • Molecular name: CCL5, CC motif chemokine ligand 5
  • Gene family: Chemokine ligands
  • Alias: RANTES; SISd; TCP228; MGC17164
  • Previous names: D17S136E; SCYA5
  • Alias:T-cell specific protein p288;


    CCL5 molecular target review


    Chemokine ligand 5 (CCL5), also known as RANTES, is a chemotactic cytokine. It can chemotactic T cells, eosinophils and basophils, and plays an active role in recruiting leukocytes to inflammatory sites. With the help of cytokines released by T cells such as IL-2 and IFN-γ, CCL5 can induce the proliferation and activation of certain natural killer (NK) cells to form CC chemokine-activated killer (CHAK) cells. CCL5 is also an HIV inhibitory factor released by CD8+ T cells. Recently, researchers are developing a protocol to improve the production of CCL5 in lactic acid bacteria in vivo, in the hope that it can become a local bactericidal agent to inhibit HIV entry.


    Human CCL5 molecular target information


    Molecular name: CCL5, CC motif chemokine ligand 5


    Alias:

    • beta-chemokine RANTES
    • CC motif chemokine 5
    • chemokine (CC motif) ligand 5
    • D17S136E
    • eoCP
    • eosinophil chemotactic cytokine
    • MGC17164
    • RANTES
    • regulated upon activation, normally T-expressed, and presumably secreted
    • SCYA5
    • SIS-delta
    • SISd
    • small inducible cytokine A5 (RANTES)
    • small inducible cytokine subfamily A (Cys-Cys), member 5
    • small-inducible cytokine A5
    • t cell-specific protein P228
    • T-cell specific protein p288
    • T-cell-specific protein RANTES
    • TCP228

    Gene sequence:NCBI_Gene: 6352

    Protein sequence:UniProtKB: P13501


    Human CCL5 target molecular function (prediction)


    Enables several functions, including enzyme activator activity; phosphatidylinositol phospholipase C activity; and signaling receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell migration; and positive regulation of cell-cell adhesion. Acts upstream of or within positive regulation of T cell migration. Predicted to be located in cytoplasm. B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Biomarker of several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); hypertension (multiple); liver cirrhosis (multiple); and lung disease (multiple).


    Mouse Ccl5 molecular target information


    Molecular name: Ccl5, chemokine (CC motif) ligand 5


    Alias:

    • MuRantes
    • RANTES
    • Scya5
    • SISd
    • small inducible cytokine A5
    • TCP228


    Gene sequence:NCBI_Gene: 20304

    Protein sequence:


    Mouse Ccl5 target molecular function (prediction)


    Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; gonad; hemolymphoid system; late tubule; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (CC motif chemokine ligand 5).


    Rat Ccl5 molecular target information


    Molecular name: Ccl5, CC motif chemokine ligand 5

    Alias:

    • CC motif chemokine 5
    • chemokine (CC motif) ligand 5
    • RANTES
    • regulated upon activation normal T-cell expressed and secreted
    • Scya5
    • SIS-delta
    • small inducible cytokine A5
    • small inducible cytokine A5 (RANTES)
    • small-inducible cytokine A5
    • T-cell-specific protein RANTES

    Gene sequence:NCBI_Gene: 81780

    Protein sequence:


    Rat Ccl5 target molecule function (prediction)


    Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to organonitrogen compound; lymphocyte migration; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; non-alcoholic fatty liver disease; (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (CC motif chemokine ligand 5).