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SERPINE1 molecular target information overview


  • Molecular name: SERPINE1, serpin family E member 1
  • Gene family: Serpin peptidase inhibitors
  • Alias: PAI
  • Previous name: PLANH1; PAI1
  • Alias: plasminogen activator inhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1


    • Overview of SERPINE1 molecular targets


    Serpin E1, also known as plasminogen activator inhibitor-1 (PAI-1), is a member of the serine protease inhibitor superfamily and is primarily produced by the endothelium (vascular endothelial lining cells), but is also secreted by other types of tissues such as adipose tissue. Serpin E1 is the main inhibitor of urokinase and tissue-type plasminogen activator (uPA and tPA). The PA-plasmin system is involved in a variety of physiological and pathological processes such as fibrinolysis, fibrosis, angiogenesis, wound healing, tumor cell invasion and metastasis. For example, high levels of uPA and Serpin E1 are associated with poor prognosis in breast cancer patients, and studies have confirmed that the clinical value of uPA and Serpin E1 is at the 1 level and is the most reliable biomarker. In addition to breast cancer, Serpin E1 is also involved in many other diseases such as metabolic syndrome, asthma, major depressive disorder (MDD), and aging-related diseases. The absence of Serpin E1 in plasma will lead to abnormal bleeding, and high levels of Serpin E1 are associated with hereditary thrombophilia.


    Human SERPINE1 Molecular Target Information


    Molecular name: SERPINE1, serpin family E member 1


    Alias:

    • endothelial plasminogen activator inhibitor
    • PAI
    • PAI-1
    • PAI1
    • PLANH1
    • plasminogen activator inhibitor 1
    • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    • serpin E1
    • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

    Gene sequence:NCBI_Gene: 5054

    Protein sequence: UniProtKB: P05121


    Human SERPINE1 target molecular function (prediction)


    Enables protease binding activity; serine-type endopeptidase inhibitor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of proteolysis; regulation of angiogenesis; and response to bacterium. Located in collagen-containing extracellular matrix and extracellular exosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); lung disease (multiple); and sleep apnea (multiple).


    Mouse Serpine1 molecular target information


    Molecular name:Serpine1, serine (or cysteine) peptidase inhibitor, clade E, member 1


    Alias:

    • PAI-1
    • PAI1
    • Planh1
    • plasminogen activator inhibitor, type I


    Gene sequence:NCBI_Gene: 18787

    Protein sequence:


    Mouse Serpine1 target molecular function (prediction)


    Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).


    Rat Serpine1 molecular target information


    Molecular name: Serpine1, serpin family E member 1

    Alias:

    • endothelial plasminogen activator inhibitor
    • PAI
    • PAI-1
    • Pai1
    • PAI1A
    • Pai1aa
    • Planh
    • Plasminogen activator inhibitor
    • plasminogen activator inhibitor 1
    • RATPAI1A
    • serine (or cysteine) peptidase inhibitor, clade E, member 1
    • serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1
    • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
    • serine (or cysteine) proteinase inhibitor, clade E, member 1
    • serine (or cysteine) proteinase inhibitor, member 1
    • serpin E1
    • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

    Gene sequence:NCBI_Gene: 24617

    Protein sequence:


    Rat Serpine1 target molecular function (prediction)


    Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); 1).