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IL20 molecular target information overview


  • Molecular name: IL20, interleukin 20
  • Gene family: Interleukins
  • Other names: ZCYTO10; IL10D; IL-20


    • Overview of IL20 molecular targets


    Interleukin 2 (IL-2) is a 15 kDa glycoprotein that is encoded by a single gene located in the q26-28 region of chromosome 4 in humans. It is a signaling molecule in the immune system that regulates the activity of white blood cells (leukocytes, usually lymphocytes) that have immune functions. IL-2 is the body's natural response to microbial infection, distinguishing between foreign and self antigens. IL-2 functions by binding to the IL-2 receptor, which consists of three chains: the alpha chain (CD25), the beta chain (CD122), and the gamma chain (CD132). Monitoring IL-2 levels in serum provides a more detailed view of a variety of pathological conditions, including cancer, infectious diseases, transplant rejection, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.


    Human IL20 Molecular Target Information


    Molecular name: IL20, interleukin 20


    Alias:

    • cytokine Zcyto10
    • four alpha helix cytokine
    • IL-20
    • IL10D
    • interleukin-20
    • MGC96907
    • ZCYTO10

    Gene sequence:NCBI_Gene: 50604

    Protein sequence:UniProtKB: Q9NYY1


    Human IL20 target molecular function (prediction)


    Predicted to enable interleukin-20 receptor binding activity. Predicted to be involved in positive regulation of keratinocyte differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of inflammatory response. Predicted to act upstream of or within positive regulation of osteoclast differentiation.


    Mouse Il20 molecular target information


    Molecular name: Il20, interleukin 20


    Other Names:

    • Zcyto10


    Gene sequence:NCBI_Gene: 58181

    Protein sequence:


    Mouse Il20 target molecular function (prediction)


    Enables cytokine activity; interleukin-20 receptor binding activity; and interleukin-22 receptor binding activity. Acts upstream of or within positive regulation of osteoclast differentiation. Located in extracellular space. Is expressed in Harderian gland; ductus deferens; epididymis; prostate gland; and skin. Human ortholog(s) of this gene implicated in psoriasis. Orthologous to human IL20 (interleukin 20).


    Rat Il20 molecular target information


    Molecular name: Il20, interleukin 20

    Alias:

    • If2d
    • interferon 2d
    • interleukin-20
    • LOC681112
    • similar to interleukin 20

    Gene sequence:NCBI_Gene: 681112

    Protein sequence:UniProtKB: D4A2T8


    Rat Il20 target molecular function (prediction)


    Predicted to enable cytokine activity; interleukin-20 receptor binding activity; and interleukin-22 receptor binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of osteoclast differentiation. Predicted to be located in extracellular space. Biomarker of end stage renal disease. Human ortholog(s) of this gene implicated in psoriasis. Orthologous to human IL20 (interleukin 20).