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Overview of MOK molecular target information


  • Molecular name: MOK, MOK protein kinase
  • Other names: RAGE1; STK30
  • Former name: RAGE
  • Alias: renal tumor antigen


    • Overview of MOK molecular targets


    The receptor for advanced glycation end products (RAGE) is a 35 kDa transmembrane receptor of the immunoglobulin superfamily, and its name comes from its ability to bind to advanced glycation end products. Given its inflammatory function in innate immunity and its ability to recognize a class of ligands through a common motif, RAGE is generally considered a class of recognition receptors. RAGE is associated with several chronic diseases, such as atherosclerosis, peripheral vascular disease, myocardial infarction, congestive heart failure, diabetes, Alzheimer's disease, etc. Compared with other tissues, RAGE is most highly expressed in the lungs, especially in type I alveolar epithelial cells, but is not expressed in idiopathic pulmonary fibrosis (IPF), indicating that the expression and regulation of RAGE in the lung system is different from that in the cardiovascular system. Blocking/knockout of RAGE leads to impaired cell adhesion and increased cell proliferation and migration.


    Human MOK molecular target information


    Molecular name: MOK, MOK protein kinase


    Alias:

    • MAPK/MAK/MRK overlapping kinase
    • RAGE
    • RAGE-1
    • RAGE1
    • renal cell carcinoma antigen
    • renal cell carcinoma antigen (MOK protein kinase)
    • renal tumor antigen 1
    • STK30

    Gene sequence:NCBI_Gene: 5891

    Protein sequence:UniProtKB: Q9UQ07


    Human MOK target molecular function (prediction)


    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in ciliary base. Predicted to be active in cytoplasm and nucleus. Biomarker of renal cell carcinoma.


    Mouse Mok molecular target information


    Molecular name: Mok, MOK protein kinase


    Alias:

    • MAPK/MAK/MRK/ overlapping kinase
    • MOK
    • Rage
    • renal tumor antigen
    • serine/threonine kinase 30
    • Stk30


    Gene sequence:NCBI_Gene: 26448

    Protein sequence:


    Mouse Mok target molecular function (prediction)


    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Located in ciliary base and nucleus. Is expressed in gonad. Orthologous to human MOK (MOK protein kinase).


    Rat Mok molecular target information


    Molecular name: Mok, MOK protein kinase

    Alias:

    • LOC362787
    • MAPK/MAK/MRK overlapping kinase
    • MGC94988
    • Rage
    • renal tumor antigen

    Gene sequence:NCBI_Gene: 362787

    Protein sequence:


    Rat Mok target molecular function (prediction)


    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in ciliary base. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOK (MOK protein kinase).