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CA14 Molecular Target Information Overview


  • Molecular name: CA14, carbonic anhydrase 14
  • Gene family: Carbonic anhydrases
  • Alias: carbonic anhydrase XIV


    • CA14 molecular target review


    Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic anhydrases are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They have a wide tissue distribution and diverse subcellular localization. Carbonic anhydrase 14 (CA14) is a polypeptide consisting of an extracellular N-terminal catalytic domain, a transmembrane region, and a short intracellular C-terminal fragment with potential phosphorylation sites. CA14 is expressed on the plasma membranes of the cell bodies and axons of brain neurons, on the plasma membranes of hepatocytes in the liver, and also preferentially on the apical membranes of the proximal tubules in the kidney. CA14 shares the highest sequence similarity with another transmembrane CA isoform, CA12. However, they have different tissue-specific expression patterns and may therefore play different physiological roles. CA14 and CA4 regulate the intracellular pH of hippocampal neurons by promoting AE3-mediated Cl- – HCO3- exchange.


    Human CA14 Molecular Target Information


    Molecular name: CA14, carbonic anhydrase 14


    Alias:

    • CA-XIV
    • carbonate dehydratase XIV
    • carbonic anhydrase XIV
    • carbonic dehydratase
    • CAXiV

    Gene sequence:NCBI_Gene: 23632

    Protein sequence:UniProtKB: Q9ULX7


    Human CA14 target molecular function (prediction)


    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane.


    Mouse Car14 molecular target information


    Molecular name: Car14, carbonic anhydrase 14


    Alias:

    • AW536446
    • CA XIV
    • expressed sequence AW536446


    Gene sequence:NCBI_Gene: 23831

    Protein sequence:


    Mouse Car14 target molecular function (prediction)


    Enables carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; cranium; epiblast; eye; and urinary system. 14).


    Rat Ca14 molecular target information


    Molecular name: Ca14, carbonic anhydrase 14

    Alias:

    • Car14
    • carbonic anhydrase XIV

    Gene sequence:NCBI_Gene: 791259

    Protein sequence:UniProtKB: A2IBE0


    Rat Ca14 target molecular function (prediction)


    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human CA14 (carbonic anhydrase 14).