MMP3 molecular target information overview
Overview of MMP3 molecular targets
Matrix metalloproteinase 3 (MMP-3), also known as stromelysin-1, is encoded by the MMP3 gene in humans. MMP3 expression is primarily regulated at the transcriptional level, where the gene promoter responds to a variety of stimuli including growth factors, cytokines, tumor promoters, and oncogene products. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can activate other MMPs such as MMP-1, MMP-7, and MMP-9, thus playing a key role in connective tissue remodeling. The enzyme is involved in wound repair, atherosclerosis progression, and tumor initiation. Studies in MMP-3 wild-type and knockout mice have shown that MMP-3 increases blood-brain barrier permeability after traumatic injury. Nuclear MMP-3 can function as both a transcription factor and a protease.
Human MMP3 molecular target information
Molecular name: MMP3, matrix metallopeptidase 3
Alias:
- CHDS6
- matrix metallopeptidase 3 (stromelysin 1, progelatinase)
- matrix metalloproteinase 3 (stromelysin 1, progelatinase)
- matrix metalloproteinase-3
- MGC126102
- MGC126103
- MGC126104
- MMP-3
- proteoglycanase
- SL-1
- STMY
- STMY1
- STR1
- stromelysin-1
- transin-1
Gene sequence:NCBI_Gene: 4314
Protein sequence:UniProtKB: P08254
Human MMP3 target molecular function (prediction)
Enables endopeptidase activity and metallopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of hydrogen peroxide metabolic process; and positive regulation of protein-containing complex assembly. Predicted to be located in cytosol and mitochondrion. Implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Biomarker of several diseases, including Takayasu's arteritis; arthritis (multiple); autoimmune disease (multiple); conjunctivochalasis; and lung disease (multiple).
Mouse Mmp3 molecular target information
Molecular name: Mmp3, matrix metallopeptidase 3
Alias:
- progelatinase
- SLN-1
- SLN1
- Stmy1
- STR-1
- Str1
- stromelysin 1
- stromelysin-1
Gene sequence:NCBI_Gene: 17392
Protein sequence:
Mouse Mmp3 target molecular function (prediction)
Predicted to enable metalloendopeptidase activity. Involved in several processes, including negative regulation of protein kinase B signaling; positive regulation of oxidative stress-induced cell death; and protein catabolic process. Acts upstream of or within cellular response to amino acid stimulus and regulation of cell migration. Located in cytosol and mitochondrion. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; liver; oral region epithelium; and palatal shelf. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).
Rat Mmp3 molecular target information
Molecular name: Mmp3, matrix metallopeptidase 3
Alias:
- matrix metalloproteinase 3
- matrix metalloproteinase-3
- MMP-3
- PTR1 protein
- SL-1
- stromelysin-1
- transin-1
Gene sequence:NCBI_Gene: 171045
Protein sequence:
Rat Mmp3 target molecular function (prediction)
Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in several cellular components, including cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).