CD19 molecular target information overview
CD19 molecular target review
CD19 is a 95kDa transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in all developmental stages of B cells, except plasma cells. CD19 forms a complex with CD21, CD81, and MHC class II molecules, and initiates the activation of mature B cells by interacting with B cell receptors. CD19 can promote B cell proliferation, development, and activation, as well as the maturation of memory B cells. In CD19-deficient mice, the generation and maturation of B cells in the bone marrow and periphery are affected.
Human CD19 Molecular Target Information
Molecular name: CD19, CD19 molecule
Alias:
- B-lymphocyte antigen CD19
- B-lymphocyte surface antigen B4
- B4
- cd19 antigen
- CVID3
- differentiation antigen CD19
- MGC12802
- T-cell surface antigen Leu-12
Gene sequence:NCBI_Gene: 930
Protein sequence:UniProtKB: P15391
Human CD19 target molecule function (prediction)
Involved in several processes, including B cell proliferation involved in immune response; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Located in external side of plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Implicated in common variable immunodeficiency.
Mouse Cd19 molecular target information
Molecular name: Cd19, CD19 antigen
Alias:
- AW495831
- expressed sequence AW495831
Gene sequence:NCBI_Gene: 12478
Protein sequence:
Mouse Mouse Cd19 Target Molecular Function (Prediction)
Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule).
Rat Cd19 molecular target information
Molecular name: Cd19, CD19 molecule
Alias:
- B-lymphocyte antigen CD19
- CD19 antigen
- LOC365367
- MGC109570
Gene sequence:NCBI_Gene: 365367
Protein sequence:
Rat Cd19 target molecular function (prediction)
Predicted to be involved in several processes, including B cell activation; B cell receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of protein-containing complex. in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule).