ADGRE1 molecular target information overview
ADGRE1 molecular targets review
F4/80 is a transmembrane protein that is also expressed on Kupffer cells and Langerhans cells, but it can still be used as a marker for macrophages. Bone marrow cells upregulate F4/80 antigen expression after being stimulated with macrophage colony stimulating factor in vitro. The induction of CD8+ T cell-mediated peripheral tolerance also requires the participation of F4/80.
Human ADGRE1 Molecular Target Information
Molecular name:ADGRE1, adhesion G protein-coupled receptor E1
Alias:
- egf-like module containing, mucin-like, hormone receptor-like 1
- egf-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-like module receptor 1
- EGF-like module-containing mucin-like hormone receptor-like 1
- EMR1
- EMR1 hormone receptor
- TM7LN3
Gene sequence:NCBI_Gene: 2015
Protein sequence:UniProtKB: Q14246
Human ADGRE1 target molecular function (prediction)
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane.
Mouse Adgre1 molecular target information
Molecular name:Adgre1, adhesion G protein-coupled receptor E1
Alternate names:
- DD7A5-7
- EGF-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-TM7
- Emr1
- F4/80
- glycoprotein f4/80 protein
- Gpf480
- Ly71
- lymphocyte antigen 71
- TM7LN3
Gene sequence:NCBI_Gene: 13733
Protein sequence:
- UniprotKB: Q61549
- UniprotKB: A0A3B2W7X0
- UniprotKB: A0A3B2W8A7
- UniprotKB: A0A3B2WB94
- UniprotKB: O08743
- UniprotKB: O08744
- UniprotKB: O08745
- UniprotKB: Q3S4B0
- UniprotKB: Q3U1M9
- UniprotKB: Q3U9R0
- UniprotKB: Q6LCD7
Mouse Adgre1 target molecular function (prediction)
Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integral system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
Rat Adgre1 molecular target information
Molecular name:Adgre1, adhesion G protein-coupled receptor E1
Alias:
- adhesion G protein-coupled receptor E2
- cell surface glycoprotein EMR1
- EGF-like module containing, mucin-like, hormone receptor-like 1
- EGF-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-like module receptor 1
- EGF-like module-containing mucin-like hormone receptor-like 1
- Emr1
- EMR1 hormone receptor
Gene sequence:NCBI_Gene: 316137
Protein sequence:UniProtKB: Q5Y4N8
Rat Adgre1 target molecular function (prediction)
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1).