IGF1 molecular target information overview
Overview of IGF1 molecular targets
Insulin-like growth factor 1 (IGF-1), also known as somatomedin C, is a hormone that is similar in molecular structure to insulin. IGF-1 is primarily produced by the liver as an endocrine hormone. Similarly, target tissues can also produce IGF-1 paracrinely/autocrinely. IGF-1 is a potent natural activator of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. IGF-1 binds to at least two cell surface receptors: the IGF-1 receptor (IGF1R) and the insulin receptor. IGF-1 production is stimulated by growth hormone and inhibited by malnutrition, growth hormone insensitivity, lack of growth hormone receptors, or malfunction of signaling pathways downstream of the growth hormone receptor (SHP2 and STAT5B). IGF-1 plays an important role in growth in children, and subsequently in anabolism in adults, and is associated with aging, neuropathy, cancer, and stroke.
Human IGF1 Molecular Target Information
Molecular name:IGF1, insulin like growth factor 1
Alias:
- IGF
- IGF-I
- IGF-IA
- IGF-IB
- IGF1A
- IGFI
- insulin-like growth factor 1
- insulin-like growth factor 1 (somatomedin C)
- insulin-like growth factor I
- insulin-like growth factor IA
- insulin-like growth factor IB
- mechano growth factor
- MGF
- somatomedin-C
Gene sequence:NCBI_Gene: 3479
Protein sequence:UniProtKB: P05019
Human IGF1 target molecular function (prediction)
Enables signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within cell activation. Located in extracellular space. Part of alphav-beta3 integrin-IGF-1-IGF1R complex and insulin-like growth factor ternary complex. Implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Biomarker of several diseases, including Henoch-Schoenlein purpura; artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); and eye disease (multiple).
Mouse Igf1 molecular target information
Molecular name:Igf1, insulin-like growth factor 1
Alternate names:
- C730016P09Rik
- Igf-1
- Igf-I
- RIKEN cDNA C730016P09 gene
Gene sequence:NCBI_Gene: 16000
Protein sequence:
- UniprotKB: P05017
- UniprotKB: D3Z7M4
- UniprotKB: E9PU89
- UniprotKB: E9Q138
- UniprotKB: Q4VJB9
- UniprotKB: Q4VJC0
- UniprotKB: Q547V2
- UniprotKB: Q8CAR0
Mouse Igf1 target molecular function (prediction)
Enables insulin receptor binding activity and insulin-like growth factor receptor binding activity. Involved in negative regulation of gene expression; negative regulation of release of cytochrome c from mitochondria; and positive regulation of myelination. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in exocytic vesicle and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including acne; artery disease (multiple); diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1).
Rat Igf1 molecular target information
Molecular name:Igf1, insulin-like growth factor 1
Alias:
- IGF
- IGF-I
- insulin-like growth factor I
- somatomedin
Gene sequence:NCBI_Gene: 24482
Protein sequence:
Rat Igf1 target molecular function (prediction)
Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia;