CXCL8 molecular target information overview
CXCL8 molecular target review
Interleukin 8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells, and endothelial cells. In humans, it is encoded by the IL8 gene. IL-8 is an effective promoter of angiogenesis and plays an important role in the pathogenesis of bronchiolitis. IL-8 can regulate the inflammatory response by recruiting and degranulating neutrophils, and can act on colorectal cancer as an autocrine growth factor for colon cancer cell lines. High levels of IL-8 can reduce the positive response of antipsychotic drugs in patients with schizophrenia. In addition, IL-8 is also related to the pathogenesis of obesity and cystic fibrosis.
Human CXCL8 Molecular Target Information
Molecular name: CXCL8, CXC motif chemokine ligand 8
Synonyms:
- alveolar macrophage chemotactic factor I
- beta endothelial cell-derived neutrophil activating peptide
- beta-thromboglobulin-like protein
- CXC motif chemokine 8
- chemokine (CXC motif) ligand 8
- emoctakin
- GCP-1
- GCP1
- granulocyte chemotactic protein 1
- IL8
- interleukin 8
- interleukin-8
- LECT
- LUCT
- lung giant cell carcinoma-derived chemotactic protein
- lymphocyte derived neutrophil activating peptide
- lymphocyte-derived neutrophil-activating factor
- LYNAP
- MDNCF
- MONAP
- monocyte-derived neutrophil chemotactic factor
- monocyte-derived neutrophil-activating peptide
- NAF
- NAP-1
- NAP1
- neutrophil-activating peptide 1
- SCYB8
- small inducible cytokine subfamily B, member 8
- T cell chemotactic factor
- T-cell chemotactic factor
- tumor necrosis factor-induced gene 1
Gene sequence:NCBI_Gene: 3576
Protein sequence:UniProtKB: P10145
Human CXCL8 target molecular function (prediction)
Acts upstream of or within negative regulation of cell adhesion molecule production; positive regulation of cellular biosynthetic process; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including autoimmune uveitis; bacterial gastritis; gastrointestinal system cancer (multiple); trachoma; and urinary tract infection. Biomarker of several diseases, including chikungunya; cholestasis (multiple); cystic fibrosis; liver disease (multiple); and tuberculosis (multiple).