Overview of APOH molecular target information
Overview of APOH molecular targets
Apolipoprotein H (ApoH), also known as β2-glycoprotein I, is a multifunctional apolipoprotein that is encoded by the APOH gene in humans. It is a glycoprotein synthesized by hepatocytes, one of the functions of which is to bind phospholipids. ApoH can bind to a variety of negatively charged substances, such as heparin, phospholipids, and dextran sulfate. ApoH is involved in a complex aggregation process and can alter ADP-mediated platelet aggregation. It binds to phospholipids on the surface of damaged cells, thereby preventing the activation of the innate coagulation cascade. Normally, ApoH in serum exhibits anticoagulant activity (by inhibiting coagulation factors). Its plasma concentration is closely associated with changes in metabolic syndrome and vascular lesions in type 2 diabetes, and is used as a clinical indicator for assessing cardiovascular risk.
Human APOH molecular target information
Molecular name: APOH, apolipoprotein H
Alias:
- activated protein C-binding protein
- anticardiolipin cofactor
- APC inhibitor
- apo-H
- apolipoprotein H (beta-2-glycoprotein I)
- B2G1
- B2GP1
- B2GPI
- beta-2-glycoprotein 1
- beta(2)GPI
- BG
Gene sequence:NCBI_Gene: 350
Protein sequence:UniProtKB: P02749
Human APOH target molecular function (prediction)
Enables identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Involved in several processes, including blood coagulation, intrinsic pathway; negative regulation of apoptotic process; and regulation of blood coagulation. Located in cell surface and extracellular space. Part of chylomicron; high-density lipoprotein particle; and very-low-density lipoprotein particle. Colocalizes with collagen-containing extracellular matrix. Implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Biomarker of arteriosclerosis; diabetes mellitus; diabetic retinopathy; macular retinal edema; and type 2 diabetes mellitus.
Mouse Apoh molecular target information
Molecular name: Apoh, apolipoprotein H
Alternate names:
- B2GPI
- beta-2-glycoprotein 1
- beta-2-GPI
Gene sequence:NCBI_Gene: 11818
Protein sequence:
Mouse Apoh target molecular function (prediction)
Predicted to enable identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Acts upstream of or within regulation of blood coagulation. Located in extracellular space. Is expressed in liver lobe and lung. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H).
Rat Apoh molecular target information
Molecular name: Apoh, apolipoprotein H
Alias:
- apo-H
- apolipoprotein H (beta-2-glycoprotein I)
- B2GPI
- beta-2-glycoprotein 1
- beta-2-glycoprotein I
- beta(2)GPI
- LOC287774
Gene sequence:NCBI_Gene: 287774
Protein sequence:
Rat Apoh target molecular function (prediction)
Enables lipid binding activity. Involved in several processes, including negative regulation of respiratory burst; positive regulation of triglyceride catabolic process; and triglyceride transport. Located in several cellular components, including cell surface; extracellular space; and plasma membrane. Used to study myocardial infarction and thrombosis. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H).