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TNFRSF1B molecular target information overview


  • Molecular name: TNFRSF1B, TNF receptor superfamily member 1B
  • Gene family: CD molecules; Tumor necrosis factor receptor superfamily; MicroRNA protein coding host genes
  • Alias: TNFBR; TNFR80; TNF-R75;
  • Previous name: TNFR2
  • Alias: tumor necrosis factor receptor superfamily, member 1B


    • Overview of TNFRSF1B molecular targets


    Tumor necrosis factor receptor II (TNF RII) is also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B). This protein forms a heterocomplex with TNF RI and mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, that have E3 ubiquitin ligase activity. The function of IAPs in TNF receptor signaling is unknown, however c-IAP1 is thought to enhance TNF-induced apoptosis by ubiquitinating and degrading TNF receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Genetic knockout experiments in mice have shown that this protein plays a role in protecting neurons from apoptosis by stimulating antioxidant pathways.


    Human TNFRSF1B Molecular Target Information


    Molecular name: TNFRSF1B, TNF receptor superfamily member 1B


    Alias:

    • CD120b
    • p75
    • p75 TNF receptor
    • p75TNFR
    • p80 TNF-alpha receptor
    • soluble TNFR1B variant 1
    • TBPII
    • TNF-R-II
    • TNF-R2
    • TNF-R75
    • TNF-RII
    • TNFBR
    • TNFR-II
    • TNFR1B
    • TNFR2
    • TNFR80
    • tumor necrosis factor beta receptor
    • tumor necrosis factor binding protein 2
    • tumor necrosis factor receptor 2
    • tumor necrosis factor receptor superfamily member 1B
    • tumor necrosis factor receptor superfamily, member 1B
    • tumor necrosis factor receptor type II

    Gene sequence:NCBI_Gene: 7133

    Protein sequence:UniProtKB: P20333


    Human TNFRSF1B target molecular function (prediction)


    Enables tumor necrosis factor binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to lipopolysaccharide and positive regulation of membrane protein ectodomain proteolysis. Located in membrane raft. Implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); musculoskeletal system (multiple); female reproductive organ cancer (multiple); glomerulonephritis (multiple); kidney failure (multiple); and lung disease (multiple).


    Mouse Tnfrsf1b molecular target information


    Molecular name:Tnfrsf1b, tumor necrosis factor receptor superfamily, member 1b


    Alias:

    • CD120b
    • p75
    • p75 TNFR
    • TNF-alphaR2
    • TNF-R-II
    • TNF-R2
    • TNF-R75
    • TNFalpha-R2
    • TNFBR
    • Tnfr-1
    • Tnfr2
    • TNFR80
    • TNFRII
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor 2


    Gene sequence:NCBI_Gene: 21938

    Protein sequence:


    Mouse Tnfrsf1b Target Molecular Function (Prediction)


    Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B).


    Rat Tnfrsf1b molecular target information


    Molecular name: Tnfrsf1b, TNF receptor superfamily member 1B

    Alias:

    • p75
    • p80 TNF-alpha receptor
    • TNF-R2
    • TNF-RII
    • TNFR-II
    • Tnfr2
    • tumor necrosis factor receptor 2
    • tumor necrosis factor receptor superfamily member 1B
    • tumor necrosis factor receptor superfamily, member 1b
    • tumor necrosis factor receptor type II

    Gene sequence:NCBI_Gene: 156767

    Protein sequence:UniProtKB: Q80WY6


    Rat Tnfrsf1b target molecular function (prediction)


    Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and varicosity. Used to study visual epilepsy. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B).