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CCL26 molecular target information overview


  • Molecular name: CCL26, CC motif chemokine ligand 26
  • Gene family: Chemokine ligands
  • Alias: MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1
  • Previous name: SCYA26
  • Alias:macrophage inflammatory protein 4-alpha; small inducible cytokine A26; CC chemokine IMAC; chemokine N1; thymic stroma chemokine-1; eotaxin-3; small inducible cytokine subfamily A (Cys-Cys), member 26; chemokine (CC motif) ligand 26


    • CCL26 molecular target review


    Chemokine CC ligand 26 (CCL26) is a small molecular weight cytokine belonging to the CC chemokine family, also known as eotaxin-3, macrophage inflammatory protein 4α (MIP-4α), thymic stromal chemokine 1 (TSC-1) and IMAC. It is expressed in a variety of tissues, including the heart, lungs and ovaries, as well as IL-4-stimulated endothelial cells. Eotaxin-3 exerts chemotactic effects on eosinophils and basophils by binding to the chemokine receptor CCR3 on the cell surface. Eotaxin-3, together with Eotaxin-1 and Eotaxin-2, selectively activates CCR3. The interaction of Eotaxin-3-CCR3 plays an important role in allergic diseases such as atopic dermatitis and bronchial asthma.


    Human CCL26 Molecular Target Information


    Molecular name: CCL26, CC motif chemokine ligand 26


    Alias:

    • CC motif chemokine 26
    • CC chemokine IMAC
    • chemokine (CC motif) ligand 26
    • chemokine N1
    • eotaxin-3
    • IMAC
    • macrophage inflammatory protein 4-alpha
    • MGC126714
    • MIP-4-alpha
    • MIP-4a
    • MIP-4alpha
    • SCYA26
    • small inducible cytokine A26
    • small inducible cytokine subfamily A (Cys-Cys), member 26
    • small-inducible cytokine A26
    • thymic stroma chemokine-1
    • TSC-1

    Gene sequence:NCBI_Gene: 10344

    Protein sequence: UniProtKB: Q9Y258


    Human CCL26 target molecular function (prediction)


    Enables CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular space. Implicated in asthma; eosinophilic esophagitis; and rhinitis. Biomarker of several diseases, including Churg-Strauss syndrome; dermatitis (multiple); eosinophilic esophagitis; eosinophilic gastroenteritis; and rhinitis (multiple).


    Mouse Ccl26 molecular target information


    Molecular name: Ccl26, chemokine (CC motif) ligand 26


    Alias:

    • Ccl26l
    • chemokine (CC motif) ligand 26-like
    • eotaxin-3


    Gene sequence:NCBI_Gene: 541307

    Protein sequence:


    Mouse Ccl26 target molecular function (prediction)


    Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in extracellular space. Is expressed in several structures, including aorta; bone marrow; brain; genitourinary system; and respiratory system. Human Ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (CC motif chemokine ligand 26).


    Rat Ccl26 molecular target information


    Molecular name: Ccl26, CC motif chemokine ligand 26

    Alias:

    • CC motif chemokine 26
    • chemokine (CC motif) ligand 26
    • LOC685958
    • similar to eotaxin 3-like

    Gene sequence:NCBI_Gene: 685958

    Protein sequence:UniProtKB: D3ZQG2


    Rat Ccl26 target molecule function (prediction)


    Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Involved in response to organonitrogen compound. Predicted to be active in extracellular space. Used to study asthma. Human ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (CC motif chemokine ligand 26).