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CCL2 molecular target information overview


  • Molecular name:CCL2, CC motif chemokine ligand 2
  • Gene family:Chemokine ligands
  • Alias:MCP1; MCP-1; MCAF; SMC-CF; GDCF-2; HC11; MGC9434
  • Previous name: SCYA2
  • Alias: monocyte chemotactic protein 1, homologous to mouse Sig-je; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; homologous to mouse Sig-je); chemokine (CC motif) ligand 2


    • CCL2 molecular target review


    Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein 1 (MCP-1), is a small molecular weight cytokine of the CC chemokine family. CCL2 is anchored to the plasma membrane of endothelial cells through the mucopolysaccharide side chains of proteoglycans and is mainly secreted by monocytes, macrophages and dendritic cells. CCL2 can recruit monocytes, memory T cells and dendritic cells to sites of inflammation caused by tissue damage or infection. CCL2 is involved in the pathogenesis of some diseases characterized by mononuclear cell infiltration, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is involved in the neuroinflammatory process of various diseases occurring in the central nervous system, manifested as neuronal degeneration.


    Human CCL2 Molecular Target Information


    Molecular name: CCL2, CC motif chemokine ligand 2


    Alias:

    • CC motif chemokine 2
    • chemokine (CC motif) ligand 2
    • GDCF-2
    • HC11
    • HSMCR30
    • MCAF
    • MCP-1
    • MCP1
    • MGC9434
    • monocyte chemoattractant protein 1
    • monocyte chemoattractant protein-1
    • monocyte chemotactic and activating factor
    • monocyte chemotactic protein 1
    • monocyte secretory protein JE
    • SCYA2
    • small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
    • small inducible cytokine subfamily A (Cys-Cys), member 2
    • small-inducible cytokine A2
    • SMC-CF

    Gene sequence:NCBI_Gene: 6347

    Protein sequence:UniProtKB: P13500


    Human CCL2 target molecular function (prediction)


    Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and regulation of apoptotic process. Located in extracellular region. Implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Biomarker of several diseases, including autoimmune disease (multiple); liver disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and retinal disease (multiple).


    Mouse Ccl2 molecular target information


    Molecular name: Ccl2, chemokine (CC motif) ligand 2


    Alternate names:

    • AI323594
    • expressed sequence AI323594
    • HC11
    • MCAF
    • MCP-1
    • MCP1
    • monocyte chemoattractant protein-1
    • monocyte chemotactic protein
    • Scya2
    • Sigje
    • small inducible cytokine A2
    • small inducible gene JE
    • SMC-CF


    Gene sequence:NCBI_Gene: 20296

    Protein sequence:


    Mouse Ccl2 target molecular function (prediction)


    Enables CCR2 chemokine receptor binding activity and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of leukocyte chemotaxis; and positive regulation of macromolecule metabolic process. Acts upstream of or within response to bacterium and response to wounding. Located in extracellular space. Is expressed in several structures, including heart; intestine smooth muscle circular layer; nervous system; retina; and vibrissa. Used to study age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (CC motif chemokine ligand 2).


    Rat Ccl2 molecular target information


    Molecular name: Ccl2, CC motif chemokine ligand 2

    Alias:

    • CC motif chemokine 2
    • chemokine (CC motif) ligand 2
    • immediate-early serum-responsive JE protein
    • immediate-early serum-responsive protein JE
    • MCP-1
    • monocyte chemoattractant protein 1
    • monocyte chemoattractant protein-1
    • monocyte chemotactic protein 1
    • Scya2
    • Sigje
    • small inducible cytokine A2
    • Small inducible gene JE
    • small-inducible cytokine A2

    Gene sequence:NCBI_Gene: 24770

    Protein sequence:UniProtKB: P14844


    Rat Ccl2 target molecule function (prediction)


    Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and rough endoplasmic reticulum. (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and pancreatitis (multiple). gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (CC motif chemokine ligand 2).