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B4GALT1 molecular target information overview


  • Molecular name: B4GALT1, beta-1,4-galactosyltransferase 1
  • Gene family: Beta 4-glycosyltransferases
  • Alias: beta4Gal-T1
  • Former name: GGTB2
  • Alias: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1


    • B4GALT1 molecular target review


    β-1,4-galactosyltransferase 1 (B4GALT1) is one of the seven β-1,4-galactosyltransferases that are usually found in the trans-Golgi complex and can transfer galactose to oligosaccharides. Based on sequence similarity, B4GALTs can be divided into four groups: B4GALT1 and B4GALT2, B4GALT3 and B4GALT4, B4GALT5 and B4GALT6, and B4GALT7. Among these seven enzymes, B4GALT1 is unique because it can be expressed as a membrane-bound form or a secreted form. The secreted form is only present in lactating mammary tissue, where the enzyme forms a heterodimer with α-lactalbumin to catalyze the synthesis of lactose. The membrane-bound form is found either in the Golgi apparatus, where it adds galactose to N-acetylglucosamine residues, or on the cell surface, where it acts as a recognition molecule during a variety of cell-cell and cell-matrix interactions by binding to specific oligosaccharide ligands on opposing cells or the extracellular matrix. The two enzyme forms are generated by alternate transcriptional start sites and post-translational processing. B4GALT1 deficiency results in congenital aberrations of 2D-glycosylation.


    Human B4GALT1 Molecular Target Information


    Molecular Name: B4GALT1, beta-1,4-galactosyltransferase 1


    Alias:

    • B4GAL-T1
    • beta-1,4-GalTase 1
    • beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    • beta4Gal-T1
    • CDG2D
    • DKFZp686N19253
    • GGTB2
    • glycoprotein-4-beta-galactosyltransferase 2
    • GT1
    • GTB
    • lactose synthase
    • MGC50983
    • N-acetyllactosamine synthase
    • nal synthase
    • neolactotriaosylceramide beta-1,4-galactosyltransferase
    • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
    • UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1
    • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

    Gene sequence:NCBI_Gene: 2683

    Protein sequence:UniProtKB: P15291


    Human B4GALT1 target molecular function (prediction)


    Enables several functions, including UDP-galactosyltransferase activity; manganese ion binding activity; and tubulin binding activity. Involved in oligosaccharide biosynthetic process and protein N-linked glycosylation. Located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. Implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId.


    Mouse B4galt1 molecular target information


    Molecular Name: B4galt1, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1


    Alias:

    • AA407245
    • B-1,4-GalT1
    • b1,4-Galactosyltransferase I
    • beta 1,4-Galactosyltransferase I
    • beta-1,4-GalT1
    • expressed sequence AA407245
    • galactosyltransferase 2 beta 1, 4
    • GalT
    • Ggtb
    • Ggtb2
    • glycoprotein galactosyltransferase beta 1, 4


    Gene sequence:NCBI_Gene: 14595

    Protein sequence:


    Mouse B4galt1 Target Molecular Function (Prediction)


    Acts upstream of or within several processes, including lactose biosynthetic process; single fertilization; and tube morphogenesis. Located in Golgi apparatus; cell surface; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and nervous system. Used to study IgA glomerulonephritis and endocrine system disease. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1).


    Rat B4galt1 molecular target information


    Molecular Name: B4galt1, beta-1,4-galactosyltransferase 1

    Alias:

    • b4Gal-T1
    • B4galt1_mapped
    • beta-1,4-GalTase 1
    • beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    • beta4Gal-T1
    • Ggtb2
    • Glycoprotein-4-beta-galactosyltransferase 2
    • N-acetyllactosamine synthase
    • nal synthase
    • neolactotriaosylceramide beta-1,4-galactosyltransferase
    • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
    • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
    • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (mapped)
    • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

    Gene sequence:NCBI_Gene: 24390

    Protein sequence:


    Rat B4galt1 target molecular function (prediction)


    Predicted to enable several functions, including UDP-galactosyltransferase activity; laminin binding activity involved in cell-matrix adhesion; and tubulin binding activity. Involved in response to wounding. Predicted to be located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1).