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Overview of APOM Molecular Target Information


  • Molecular name: APOM, apolipoprotein M
  • Gene family: Apolipoproteins; Lipocalins
  • Other names: G3a; NG20


    • Overview of APOM Molecular Targets


    Apolipoprotein M (Apo M) is encoded by the APOM gene in humans. The protein encoded by this gene is an apolipoprotein, a member of the apolipoprotein family. Studies have found that Apo M is associated with high-density lipoproteins and, to a lesser extent, low-density lipoproteins and triglyceride-rich lipoproteins. Apo M is secreted through the plasma membrane but remains bound to the membrane and participates in lipid transport. Studies have found that the APOM gene has two transcript variants that can encode two different isomers, but only one of them has been fully characterized. The average molecular weight of Apo M is 21253 Da, and the monoisotopic molecular weight is 21239 Da.


    Human APOM molecular target information


    Molecular name: APOM, apolipoprotein M


    Alternative name:

    • Alternative name: G3a, NG20
    • apo-M
    • G3a
    • HSPC336
    • MGC22400
    • NG20
    • NG20-like protein

    Gene sequence:NCBI_Gene: 55937

    Protein sequence:UniProtKB: O95445


    Human APOM target molecular function (prediction)


    Involved in cholesterol efflux; high-density lipoprotein particle remodeling; and negative regulation of plasma lipoprotein oxidation. Part of high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus.


    Mouse Apom molecular target information


    Molecular name: Apom, apolipoprotein M


    Alternate names:

    • 1190010O19Rik
    • G3a
    • NG20
    • RIKEN cDNA 1190010O19 gene


    Gene sequence:NCBI_Gene: 55938

    Protein sequence:


    Mouse Apom target molecular function (prediction)


    Enables antioxidant activity. Involved in several processes, including cholesterol efflux; high-density lipoprotein particle clearance; and plasma lipoprotein particle organization. Acts upstream of or within lipoprotein metabolic process and reverse cholesterol transport. Located in extracellular region. Part of discoidal high-density lipoprotein particle. Is expressed in several structures, including gut; liver; male reproductive gland or organ; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M).


    Rat Apom Molecular Target Information


    Molecular name: Apom, apolipoprotein M

    Alias:

    • apo-M
    • protein Px

    Gene sequence:NCBI_Gene: 55939

    Protein sequence: UniProtKB: P14630


    Rat Apom target molecular function (prediction)


    Predicted to enable antioxidant activity; lipid transporter activity; and phospholipid binding activity. Involved in response to glucose. Located in extracellular space. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M).