IFNL1 molecular target information overview
Overview of IFNL1 molecular targets
Interleukin 29 (IL-29), also known as interferon λ1 (IFN-λ1), is a member of the helical cytokine family and a type III interferon. Its amino acid sequence is highly similar to another type III interferon, IL-28. The IL-29 gene is found on chromosome 19 in humans, but is not present in the mouse genome. IL-29 plays an important role in host defense against microorganisms, and its gene is highly upregulated in virus-infected cells. IL-29 has significant antiviral activity and immunomodulatory properties, inhibiting viral replication by inducing cellular antiviral responses similar to those activated by IFN-α/β. However, IL-29 binds to a unique receptor, so during natural infection, this cytokine may synergize with IFN-α/β or IFN-γ to inhibit viral replication, and may also be used in combination with other cytokines to treat chronic viral infections such as hepatitis C (HCV). The antiviral activity of IL-29 includes upregulation of class I MHC expression on the cell surface and upregulation of PKR expression. The ligand/receptor complex appears to signal through the Jak-STAT pathway.
Human IFNL1 Molecular Target Information
Molecular name: IFNL1, interferon lambda 1
Alias:
- cytokine Zcyto21
- IFN-lambda-1
- IL-29
- IL29
- interferon lambda-1
- interferon-lambda-1
- interferon, lambda 1
- interleukin 29 (interferon, lambda 1)
- interleukin-29
Gene sequence:NCBI_Gene: 282618
Protein sequence:UniProtKB: Q8IU54
Human IFNL1 target molecular function (prediction)
Enables interleukin-28 receptor binding activity. Involved in several processes, including negative regulation of immune response; positive regulation of macromolecule metabolic process; and regulation of gene expression. Located in extracellular region. Part of interleukin-28 receptor complex. Implicated in COVID-19; dengue hemorrhagic fever; hepatitis C; and hepatocellular carcinoma. Biomarker of asthma; dengue disease; subacute sclerosing panencephalitis; and tropical spastic spastic paraparesis.
Mouse Ifnl2 molecular target information
Molecular name: Ifnl2, interferon lambda 2
Alternate names:
- EG330496
- Il28a
- interleukin 28A
- predicted gene, EG330496
Gene sequence:NCBI_Gene: 330496
Protein sequence:
Mouse Ifnl2 target molecular function (prediction)
Predicted to enable interleukin-28 receptor binding activity. Involved in defense response to virus and mucosal immune response. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3).
Rat Ifnl1 molecular target information
Molecular name: Ifnl1, interferon, lambda 1
Alias:
- If1ia2
- interferon 1ia2
- interferon lambda-2-like
- interleukin-28A-like
- LOC100911249
Gene sequence:NCBI_Gene: 100911249
Protein sequence:UniProtKB: A0A0G2JWM7
Rat Ifnl1 target molecular function (prediction)
Predicted to enable interleukin-28 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of immune response; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to human IFNL1 (interferon lambda 1); IFNL2 (interferon lambda 2); and IFNL3 (interferon lambda 3).